GRIK1 protein (Tupaia belangeri) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

GRIK1

Glutamate ionotropic receptor kainate type subunit 1. (919 aa)

Predicted Functional Partners:

ENSTBEP00000009989

0.953

GRIK4

0.952

GRIK2

0.926

ENSTBEP00000004036

0.907

DLG4

0.839

NETO1

0.630

ENSTBEP00000004275

0.616

GNG13

0.615

DLG1

0.611

ENSTBEP00000012864

0.611

Your Current Organism:

Tupaia belangeri

NCBI taxonomy Id: 37347
Other names: T. belangeri, Tupaia glis belangeri, common tree shrew, northern tree shrew

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLG1	DLG4	ENSTBEP00000010705	ENSTBEP00000000259	Discs large MAGUK scaffold protein 1.	Discs large MAGUK scaffold protein 4.	0.884
DLG1	ENSTBEP00000004036	ENSTBEP00000010705	ENSTBEP00000004036	Discs large MAGUK scaffold protein 1.	annotation not available	0.685
DLG1	ENSTBEP00000004275	ENSTBEP00000010705	ENSTBEP00000004275	Discs large MAGUK scaffold protein 1.	annotation not available	0.781
DLG1	ENSTBEP00000009989	ENSTBEP00000010705	ENSTBEP00000009989	Discs large MAGUK scaffold protein 1.	annotation not available	0.592
DLG1	GRIK1	ENSTBEP00000010705	ENSTBEP00000002011	Discs large MAGUK scaffold protein 1.	Glutamate ionotropic receptor kainate type subunit 1.	0.611
DLG1	GRIK2	ENSTBEP00000010705	ENSTBEP00000007949	Discs large MAGUK scaffold protein 1.	Glutamate ionotropic receptor kainate type subunit 2.	0.637
DLG1	GRIK4	ENSTBEP00000010705	ENSTBEP00000002119	Discs large MAGUK scaffold protein 1.	Glutamate ionotropic receptor kainate type subunit 4.	0.592
DLG4	DLG1	ENSTBEP00000000259	ENSTBEP00000010705	Discs large MAGUK scaffold protein 4.	Discs large MAGUK scaffold protein 1.	0.884
DLG4	ENSTBEP00000004036	ENSTBEP00000000259	ENSTBEP00000004036	Discs large MAGUK scaffold protein 4.	annotation not available	0.744
DLG4	ENSTBEP00000004275	ENSTBEP00000000259	ENSTBEP00000004275	Discs large MAGUK scaffold protein 4.	annotation not available	0.941
DLG4	ENSTBEP00000009989	ENSTBEP00000000259	ENSTBEP00000009989	Discs large MAGUK scaffold protein 4.	annotation not available	0.764
DLG4	ENSTBEP00000012864	ENSTBEP00000000259	ENSTBEP00000012864	Discs large MAGUK scaffold protein 4.	annotation not available	0.885
DLG4	GRIK1	ENSTBEP00000000259	ENSTBEP00000002011	Discs large MAGUK scaffold protein 4.	Glutamate ionotropic receptor kainate type subunit 1.	0.839
DLG4	GRIK2	ENSTBEP00000000259	ENSTBEP00000007949	Discs large MAGUK scaffold protein 4.	Glutamate ionotropic receptor kainate type subunit 2.	0.908
DLG4	GRIK4	ENSTBEP00000000259	ENSTBEP00000002119	Discs large MAGUK scaffold protein 4.	Glutamate ionotropic receptor kainate type subunit 4.	0.689
ENSTBEP00000004036	DLG1	ENSTBEP00000004036	ENSTBEP00000010705	annotation not available	Discs large MAGUK scaffold protein 1.	0.685
ENSTBEP00000004036	DLG4	ENSTBEP00000004036	ENSTBEP00000000259	annotation not available	Discs large MAGUK scaffold protein 4.	0.744
ENSTBEP00000004036	ENSTBEP00000004275	ENSTBEP00000004036	ENSTBEP00000004275	annotation not available	annotation not available	0.492
ENSTBEP00000004036	ENSTBEP00000009989	ENSTBEP00000004036	ENSTBEP00000009989	annotation not available	annotation not available	0.950
ENSTBEP00000004036	ENSTBEP00000012864	ENSTBEP00000004036	ENSTBEP00000012864	annotation not available	annotation not available	0.685

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.851

expected number of edges:

11

PPI enrichment p-value:

5.48e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

5 of 44

2.28

3.21

4.21e-07

GO:0009636

Response to toxic substance

5 of 113

1.87

2.18

1.90e-05

GO:0098869

Cellular oxidant detoxification

4 of 54

2.1

2.12

6.20e-05

GO:0006805

Xenobiotic metabolic process

3 of 114

1.65

0.75

0.0315

GO:0046685

Response to arsenic-containing substance

2 of 18

2.27

0.75

0.0413

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016209

Antioxidant activity

4 of 56

2.08

2.18

4.20e-05

GO:0004364

Glutathione transferase activity

3 of 19

2.43

1.96

0.00021

GO:0015038

Glutathione disulfide oxidoreductase activity

2 of 3

3.05

1.58

0.0014

GO:0015036

Disulfide oxidoreductase activity

3 of 40

2.1

1.52

0.0012

GO:0016491

Oxidoreductase activity

8 of 805

1.23

1.45

5.00e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8432

Glutathione metabolism, and Epoxide hydrolase

9 of 27

2.75

9.93

1.40e-20

CL:8375

Glutathione metabolism, and Glutamate and glutamine metabolism

10 of 56

2.48

9.24

6.74e-21

CL:8434

Glutathione metabolism

8 of 22

2.79

8.91

3.59e-18

CL:8441

Glutathione peroxidase, and Glutathione S-transferase, C-terminal

7 of 12

2.99

8.46

1.08e-16

CL:8444

Glutathione S-transferase, C-terminal domain, and Thioredoxin peroxidase activity

4 of 5

3.13

4.52

5.51e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

acs00480

Glutathione metabolism

8 of 44

2.49

7.73

5.76e-17

acs00980

Metabolism of xenobiotics by cytochrome P450

6 of 45

2.35

5.26

1.19e-11

acs00982

Drug metabolism - cytochrome P450

4 of 38

2.25

3.25

3.04e-07

acs00983

Drug metabolism - other enzymes

3 of 51

2.0

1.94

0.00012

acs01100

Metabolic pathways

9 of 1303

1.07

1.31

1.12e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156590

Glutathione conjugation

4 of 33

2.31

2.66

7.08e-06

MAP-3299685

Detoxification of Reactive Oxygen Species

4 of 36

2.27

2.64

7.08e-06

MAP-211859

Biological oxidations

6 of 315

1.51

1.89

7.08e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 103

1.82

1.8

0.00014

MAP-9711123

Cellular response to chemical stress

4 of 171

1.6

1.38

0.00078

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14497

Glutathione S-transferase, C-terminal domain

2 of 9

2.57

0.79

0.0363

PF02798

Glutathione S-transferase, N-terminal domain

2 of 11

2.49

0.79

0.0363

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004046

Glutathione S-transferase, C-terminal

3 of 15

2.53

1.7

0.00072

IPR004045

Glutathione S-transferase, N-terminal

3 of 16

2.5

1.7

0.00072

IPR010987

Glutathione S-transferase, C-terminal-like

3 of 19

2.43

1.69

0.00072

IPR040079

Glutathione transferase family

3 of 21

2.38

1.68

0.00072

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

3 of 27

2.27

1.66

0.00072

(more ...)

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