STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP1DNA topoisomerase I. (765 aa)    
Predicted Functional Partners:
TDP1
tyrosyl-DNA phosphodiesterase 1.
    
 
 0.962
TOP2A
DNA topoisomerase II alpha.
   
 
 0.959
TOP2B
DNA topoisomerase II beta.
   
 
 0.959
BLM
BLM RecQ like helicase.
   
 
 0.951
ENSTBEP00000011064
annotation not available
   
 
 0.931
KCTD2
Potassium channel tetramerization domain containing 2.
    
 0.910
SUMO1
Small ubiquitin like modifier 1.
   
 0.856
POLE
DNA polymerase epsilon, catalytic subunit.
    
 
 0.844
RECQL5
RecQ like helicase 5.
   
 
 0.820
MUS81
MUS81 structure-specific endonuclease subunit.
    
 
 0.811
Your Current Organism:
Tupaia belangeri
NCBI taxonomy Id: 37347
Other names: T. belangeri, Tupaia glis belangeri, common tree shrew, northern tree shrew
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.