KCNK3 protein (Tupaia belangeri) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

KCNK3

Potassium two pore domain channel subfamily K member 3. (313 aa)

Predicted Functional Partners:

KCNK18

0.823

KCNK1

0.759

KCNK13

0.757

KCNK4

0.730

KCNK5

0.726

KCNK2

0.713

KCNK10

0.713

ENSTBEP00000001094

0.699

KCNK6

0.642

PNPLA4

0.614

Your Current Organism:

Tupaia belangeri

NCBI taxonomy Id: 37347
Other names: T. belangeri, Tupaia glis belangeri, common tree shrew, northern tree shrew

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTBEP00000001094	KCNK10	ENSTBEP00000001094	ENSTBEP00000007369	annotation not available	Potassium two pore domain channel subfamily K member 10.	0.636
ENSTBEP00000001094	KCNK13	ENSTBEP00000001094	ENSTBEP00000009969	annotation not available	Potassium two pore domain channel subfamily K member 13.	0.753
ENSTBEP00000001094	KCNK18	ENSTBEP00000001094	ENSTBEP00000008555	annotation not available	Potassium two pore domain channel subfamily K member 18.	0.731
ENSTBEP00000001094	KCNK2	ENSTBEP00000001094	ENSTBEP00000000976	annotation not available	Potassium two pore domain channel subfamily K member 2.	0.634
ENSTBEP00000001094	KCNK3	ENSTBEP00000001094	ENSTBEP00000011353	annotation not available	Potassium two pore domain channel subfamily K member 3.	0.699
ENSTBEP00000001094	KCNK4	ENSTBEP00000001094	ENSTBEP00000003714	annotation not available	Potassium two pore domain channel subfamily K member 4.	0.655
ENSTBEP00000001094	KCNK5	ENSTBEP00000001094	ENSTBEP00000013914	annotation not available	Potassium two pore domain channel subfamily K member 5.	0.655
ENSTBEP00000001094	KCNK6	ENSTBEP00000001094	ENSTBEP00000001990	annotation not available	Potassium two pore domain channel subfamily K member 6.	0.629
KCNK1	KCNK10	ENSTBEP00000003562	ENSTBEP00000007369	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 10.	0.754
KCNK1	KCNK13	ENSTBEP00000003562	ENSTBEP00000009969	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 13.	0.735
KCNK1	KCNK18	ENSTBEP00000003562	ENSTBEP00000008555	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 18.	0.787
KCNK1	KCNK2	ENSTBEP00000003562	ENSTBEP00000000976	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 2.	0.825
KCNK1	KCNK3	ENSTBEP00000003562	ENSTBEP00000011353	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 3.	0.759
KCNK1	KCNK4	ENSTBEP00000003562	ENSTBEP00000003714	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 4.	0.694
KCNK1	KCNK5	ENSTBEP00000003562	ENSTBEP00000013914	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 5.	0.665
KCNK1	KCNK6	ENSTBEP00000003562	ENSTBEP00000001990	Potassium two pore domain channel subfamily K member 1.	Potassium two pore domain channel subfamily K member 6.	0.637
KCNK10	ENSTBEP00000001094	ENSTBEP00000007369	ENSTBEP00000001094	Potassium two pore domain channel subfamily K member 10.	annotation not available	0.636
KCNK10	KCNK1	ENSTBEP00000007369	ENSTBEP00000003562	Potassium two pore domain channel subfamily K member 10.	Potassium two pore domain channel subfamily K member 1.	0.754
KCNK10	KCNK13	ENSTBEP00000007369	ENSTBEP00000009969	Potassium two pore domain channel subfamily K member 10.	Potassium two pore domain channel subfamily K member 13.	0.695
KCNK10	KCNK18	ENSTBEP00000007369	ENSTBEP00000008555	Potassium two pore domain channel subfamily K member 10.	Potassium two pore domain channel subfamily K member 18.	0.678

page 1 of 5

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070995

NADPH oxidation

2 of 8

3.19

2.26

0.0023

GO:0006805

Xenobiotic metabolic process

3 of 114

2.21

2.09

0.0022

GO:0062012

Regulation of small molecule metabolic process

3 of 184

2.0

1.96

0.0023

GO:0019216

Regulation of lipid metabolic process

3 of 192

1.99

1.95

0.0023

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004499

N,N-dimethylaniline monooxygenase activity

3 of 9

3.32

5.32

5.44e-07

GO:0050661

NADP binding

3 of 48

2.59

3.83

1.72e-05

GO:0050660

Flavin adenine dinucleotide binding

3 of 84

2.35

3.23

6.55e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9570

Flavin-binding monooxygenase-like, and NADPH oxidation

3 of 5

3.57

5.72

2.08e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-217271

FMO oxidises nucleophiles

2 of 8

3.19

2.47

0.0013

MAP-211945

Phase I - Functionalization of compounds

3 of 207

1.95

2.08

0.0013

MAP-211859

Biological oxidations

3 of 315

1.77

1.74

0.0027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

3 of 59

2.5

3.89

1.14e-05

KW-0503

Monooxygenase

3 of 95

2.29

3.61

1.53e-05

KW-0521

NADP

2 of 39

2.5

2.48

0.00092

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00743

Flavin-binding monooxygenase-like

2 of 2

3.79

3.16

0.00022

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