ENSTBEP00000015087 protein (Tupaia belangeri)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSTBEP00000015087

annotation not available (218 aa)

Predicted Functional Partners:

FNTA

0.998

CCDC112

0.644

GART

0.561

SAMM50

0.503

HEYL

0.502

HEY2

0.502

HEY1

0.502

ICMT

0.470

HES3

0.445

ENSTBEP00000010283

0.445

Your Current Organism:

Tupaia belangeri

NCBI taxonomy Id: 37347
Other names: T. belangeri, Tupaia glis belangeri, common tree shrew, northern tree shrew

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC112	ENSTBEP00000015087	ENSTBEP00000001020	ENSTBEP00000015087	Coiled-coil domain containing 112.	annotation not available	0.644
ENSTBEP00000010283	ENSTBEP00000015087	ENSTBEP00000010283	ENSTBEP00000015087	annotation not available	annotation not available	0.445
ENSTBEP00000010283	HES3	ENSTBEP00000010283	ENSTBEP00000002425	annotation not available	Hes family bHLH transcription factor 3.	0.814
ENSTBEP00000010283	HEY1	ENSTBEP00000010283	ENSTBEP00000008950	annotation not available	Hes related family bHLH transcription factor with YRPW motif 1.	0.540
ENSTBEP00000010283	HEY2	ENSTBEP00000010283	ENSTBEP00000007666	annotation not available	Hes related family bHLH transcription factor with YRPW motif 2.	0.540
ENSTBEP00000010283	HEYL	ENSTBEP00000010283	ENSTBEP00000000965	annotation not available	Hes related family bHLH transcription factor with YRPW motif like.	0.540
ENSTBEP00000015087	CCDC112	ENSTBEP00000015087	ENSTBEP00000001020	annotation not available	Coiled-coil domain containing 112.	0.644
ENSTBEP00000015087	ENSTBEP00000010283	ENSTBEP00000015087	ENSTBEP00000010283	annotation not available	annotation not available	0.445
ENSTBEP00000015087	FNTA	ENSTBEP00000015087	ENSTBEP00000010083	annotation not available	Farnesyltransferase, CAAX box, alpha.	0.998
ENSTBEP00000015087	GART	ENSTBEP00000015087	ENSTBEP00000001529	annotation not available	annotation not available	0.561
ENSTBEP00000015087	HES3	ENSTBEP00000015087	ENSTBEP00000002425	annotation not available	Hes family bHLH transcription factor 3.	0.445
ENSTBEP00000015087	HEY1	ENSTBEP00000015087	ENSTBEP00000008950	annotation not available	Hes related family bHLH transcription factor with YRPW motif 1.	0.502
ENSTBEP00000015087	HEY2	ENSTBEP00000015087	ENSTBEP00000007666	annotation not available	Hes related family bHLH transcription factor with YRPW motif 2.	0.502
ENSTBEP00000015087	HEYL	ENSTBEP00000015087	ENSTBEP00000000965	annotation not available	Hes related family bHLH transcription factor with YRPW motif like.	0.502
ENSTBEP00000015087	ICMT	ENSTBEP00000015087	ENSTBEP00000001691	annotation not available	Isoprenylcysteine carboxyl methyltransferase.	0.470
ENSTBEP00000015087	SAMM50	ENSTBEP00000015087	ENSTBEP00000001347	annotation not available	SAMM50 sorting and assembly machinery component.	0.503
FNTA	ENSTBEP00000015087	ENSTBEP00000010083	ENSTBEP00000015087	Farnesyltransferase, CAAX box, alpha.	annotation not available	0.998
FNTA	HEYL	ENSTBEP00000010083	ENSTBEP00000000965	Farnesyltransferase, CAAX box, alpha.	Hes related family bHLH transcription factor with YRPW motif like.	0.414
FNTA	ICMT	ENSTBEP00000010083	ENSTBEP00000001691	Farnesyltransferase, CAAX box, alpha.	Isoprenylcysteine carboxyl methyltransferase.	0.563
GART	ENSTBEP00000015087	ENSTBEP00000001529	ENSTBEP00000015087	annotation not available	annotation not available	0.561

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.728

expected number of edges:

14

PPI enrichment p-value:

3.99e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

4 of 62

2.02

2.15

4.11e-05

GO:0070828

Heterochromatin organization

4 of 68

1.98

2.1

4.74e-05

GO:0050872

White fat cell differentiation

3 of 22

2.34

1.97

0.00019

GO:0045444

Fat cell differentiation

4 of 124

1.72

1.59

0.00034

GO:0006325

Chromatin organization

7 of 523

1.34

1.54

1.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001222

Transcription corepressor binding

6 of 58

2.22

4.11

2.51e-09

GO:0042826

Histone deacetylase binding

4 of 130

1.7

1.55

0.00040

GO:0098882

Structural constituent of presynaptic active zone

2 of 6

2.73

1.51

0.0018

GO:0051287

NAD binding

3 of 64

1.88

1.39

0.0016

GO:0008134

Transcription factor binding

7 of 660

1.24

1.35

3.15e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035098

ESC/E(Z) complex

4 of 12

2.73

3.71

1.20e-07

GO:0016581

NuRD complex

4 of 18

2.56

3.42

3.22e-07

GO:0017053

Transcription repressor complex

5 of 82

2.0

2.96

3.76e-07

GO:0005667

Transcription regulator complex

10 of 518

1.5

2.86

8.60e-12

GO:0016589

NURF complex

3 of 8

2.78

2.8

6.96e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7538

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Histone methyltransferase activity (H3-K9 specific)

4 of 7

2.97

3.81

1.01e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05220

Chronic myeloid leukemia

6 of 87

2.05

3.82

2.68e-09

map04330

Notch signaling pathway

4 of 69

1.97

2.31

1.45e-05

map05200

Pathways in cancer

6 of 558

1.24

1.33

4.55e-05

map04310

Wnt signaling pathway

3 of 205

1.38

0.78

0.0190

map04218

Cellular senescence

3 of 198

1.39

0.78

0.0190

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 63

2.11

3.02

5.36e-07

MAP-8943724

Regulation of PTEN gene transcription

5 of 71

2.06

2.97

5.36e-07

MAP-6804758

Regulation of TP53 Activity through Acetylation

4 of 40

2.21

2.74

3.58e-06

MAP-3214815

HDACs deacetylate histones

4 of 41

2.2

2.73

3.58e-06

MAP-4641265

Repression of WNT target genes

3 of 13

2.57

2.54

1.84e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001688

Cochlear ganglion

2 of 3

3.03

1.2

0.0069

BTO:0003667

Inner hair cell

2 of 6

2.73

1.19

0.0069

BTO:0004725

Embryonic fibroblast

3 of 142

1.53

0.76

0.0276

BTO:0000379

Embryo

5 of 1013

0.9

0.51

0.0345

BTO:0000174

Embryonic structure

6 of 1491

0.81

0.49

0.0276

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035098

ESC/E(Z) complex

4 of 11

2.77

3.6

2.07e-07

GOCC:0098831

Presynaptic active zone cytoplasmic component

3 of 15

2.51

2.23

6.89e-05

GOCC:0098681

Synaptic ribbon

2 of 3

3.03

1.67

0.00096

GOCC:0098684

Photoreceptor ribbon synapse

2 of 10

2.51

1.27

0.0046

GOCC:0090545

CHD-type complex

2 of 11

2.47

1.26

0.0048

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12265

Histone-binding protein RBBP4 or subunit C of CAF1 complex

3 of 3

3.21

2.83

7.69e-06

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 4

3.08

2.82

7.69e-06

PF08504

Runx inhibition domain

2 of 3

3.03

1.44

0.0025

PF00853

Runt domain

2 of 3

3.03

1.44

0.0025

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