PBRA_000029 protein (Plasmodiophora brassicae)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

PBRA_000029

Nuclear cap-binding protein subunit 2. (209 aa)

Predicted Functional Partners:

PBRA_007629

0.999

PBRA_000079

0.991

PBRA_001644

0.989

PBRA_004937

0.983

PBRA_006225

0.982

PBRA_009315

0.982

PBRA_008257

0.979

PBRA_001619

0.975

PBRA_008620

0.975

PBRA_003752

0.974

Your Current Organism:

Plasmodiophora brassicae

NCBI taxonomy Id: 37360
Other names: P. brassicae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PBRA_000029	PBRA_000079	A0A0G4IGF9	A0A0G4IGJ0	Nuclear cap-binding protein subunit 2.	C2H2-type domain-containing protein.	0.991
PBRA_000029	PBRA_001619	A0A0G4IGF9	A0A0G4IZ15	Nuclear cap-binding protein subunit 2.	Small nuclear ribonucleoprotein G.	0.975
PBRA_000029	PBRA_001644	A0A0G4IGF9	A0A0G4IZ39	Nuclear cap-binding protein subunit 2.	RRM domain-containing protein.	0.989
PBRA_000029	PBRA_003752	A0A0G4IGF9	A0A0G4IIE7	Nuclear cap-binding protein subunit 2.	Sm domain-containing protein.	0.974
PBRA_000029	PBRA_004937	A0A0G4IGF9	A0A0G4ILY3	Nuclear cap-binding protein subunit 2.	Small nuclear ribonucleoprotein Sm D2.	0.983
PBRA_000029	PBRA_006225	A0A0G4IGF9	A0A0G4ISP2	Nuclear cap-binding protein subunit 2.	SLBP_RNA_bind domain-containing protein.	0.982
PBRA_000029	PBRA_007629	A0A0G4IGF9	A0A0G4IX35	Nuclear cap-binding protein subunit 2.	Uncharacterized protein.	0.999
PBRA_000029	PBRA_008257	A0A0G4IGF9	A0A0G4J034	Nuclear cap-binding protein subunit 2.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.979
PBRA_000029	PBRA_008620	A0A0G4IGF9	A0A0G4J241	Nuclear cap-binding protein subunit 2.	NTF2 domain-containing protein.	0.975
PBRA_000029	PBRA_009315	A0A0G4IGF9	A0A0G4J6H6	Nuclear cap-binding protein subunit 2.	Small nuclear ribonucleoprotein Sm D3.	0.982
PBRA_000079	PBRA_000029	A0A0G4IGJ0	A0A0G4IGF9	C2H2-type domain-containing protein.	Nuclear cap-binding protein subunit 2.	0.991
PBRA_000079	PBRA_003752	A0A0G4IGJ0	A0A0G4IIE7	C2H2-type domain-containing protein.	Sm domain-containing protein.	0.582
PBRA_000079	PBRA_004937	A0A0G4IGJ0	A0A0G4ILY3	C2H2-type domain-containing protein.	Small nuclear ribonucleoprotein Sm D2.	0.431
PBRA_000079	PBRA_007629	A0A0G4IGJ0	A0A0G4IX35	C2H2-type domain-containing protein.	Uncharacterized protein.	0.985
PBRA_001619	PBRA_000029	A0A0G4IZ15	A0A0G4IGF9	Small nuclear ribonucleoprotein G.	Nuclear cap-binding protein subunit 2.	0.975
PBRA_001619	PBRA_001644	A0A0G4IZ15	A0A0G4IZ39	Small nuclear ribonucleoprotein G.	RRM domain-containing protein.	0.701
PBRA_001619	PBRA_003752	A0A0G4IZ15	A0A0G4IIE7	Small nuclear ribonucleoprotein G.	Sm domain-containing protein.	0.999
PBRA_001619	PBRA_004937	A0A0G4IZ15	A0A0G4ILY3	Small nuclear ribonucleoprotein G.	Small nuclear ribonucleoprotein Sm D2.	0.999
PBRA_001619	PBRA_006225	A0A0G4IZ15	A0A0G4ISP2	Small nuclear ribonucleoprotein G.	SLBP_RNA_bind domain-containing protein.	0.657
PBRA_001619	PBRA_007629	A0A0G4IZ15	A0A0G4IX35	Small nuclear ribonucleoprotein G.	Uncharacterized protein.	0.982

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.914

expected number of edges:

15

PPI enrichment p-value:

6.1e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031564

Transcription antitermination

3 of 5

2.37

2.19

6.93e-05

GO:0006353

DNA-templated transcription, termination

3 of 5

2.37

2.19

6.93e-05

GO:0035999

Tetrahydrofolate interconversion

3 of 10

2.07

1.83

0.00025

GO:0000105

Histidine biosynthetic process

3 of 16

1.86

1.57

0.00059

GO:0009086

Methionine biosynthetic process

3 of 22

1.72

1.4

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004488

Methylenetetrahydrofolate dehydrogenase (NADP+) activity

3 of 3

2.59

2.04

0.00017

GO:0004477

Methenyltetrahydrofolate cyclohydrolase activity

3 of 3

2.59

2.04

0.00017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 338

0.84

0.57

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:958

Folic acid-containing compound metabolic process, and Deoxyribonucleotide biosynthetic process

4 of 18

1.94

1.85

0.00016

CL:861

Mixed, incl. Nucleoside monophosphate metabolic process, and Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

5 of 82

1.37

1.24

0.00061

CL:978

Tetrahydrofolate interconversion

2 of 5

2.19

0.88

0.0235

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

4 of 26

1.78

1.88

7.53e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0889

Transcription antitermination

3 of 3

2.59

2.31

5.08e-05

KW-0554

One-carbon metabolism

3 of 8

2.16

1.9

0.00021

KW-0486

Methionine biosynthesis

3 of 10

2.07

1.83

0.00024

KW-0511

Multifunctional enzyme

3 of 11

2.03

1.82

0.00024

KW-0658

Purine biosynthesis

3 of 15

1.89

1.65

0.00041

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

2.05

0.00016

PF00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

2.05

0.00016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020631

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

1.84

0.00040

IPR020630

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

1.84

0.00040

IPR000672

Tetrahydrofolate dehydrogenase/cyclohydrolase

3 of 3

2.59

1.84

0.00040

IPR046346

Aminoacid dehydrogenase-like, N-terminal domain superfamily

3 of 6

2.29

1.78

0.00042

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