PBRA_005964 protein (Plasmodiophora brassicae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

PBRA_005964

Uncharacterized protein. (893 aa)

Predicted Functional Partners:

PBRA_000447

0.999

PBRA_001576

0.999

PBRA_008423

0.999

PBRA_004859

0.996

PBRA_003327

0.985

PBRA_005763

0.983

PBRA_002235

0.983

PBRA_001606

0.982

PBRA_002688

0.982

PBRA_004384

0.972

Your Current Organism:

Plasmodiophora brassicae

NCBI taxonomy Id: 37360
Other names: P. brassicae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PBRA_000447	PBRA_001576	A0A0G4IHG8	A0A0G4IZ25	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.999
PBRA_000447	PBRA_001606	A0A0G4IHG8	A0A0G4IZ48	Beta-Casp domain-containing protein.	RPOLD domain-containing protein.	0.846
PBRA_000447	PBRA_002235	A0A0G4IHG8	A0A0G4J318	Beta-Casp domain-containing protein.	RPOL4c domain-containing protein.	0.835
PBRA_000447	PBRA_002688	A0A0G4IHG8	A0A0G4J636	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.837
PBRA_000447	PBRA_003327	A0A0G4IHG8	A0A0G4J835	Beta-Casp domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.898
PBRA_000447	PBRA_004384	A0A0G4IHG8	A0A0G4IKE6	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.789
PBRA_000447	PBRA_004859	A0A0G4IHG8	A0A0G4ILZ5	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.995
PBRA_000447	PBRA_005763	A0A0G4IHG8	A0A0G4IPU5	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.875
PBRA_000447	PBRA_005964	A0A0G4IHG8	A0A0G4IRF4	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.999
PBRA_000447	PBRA_008423	A0A0G4IHG8	A0A0G4J1G6	Beta-Casp domain-containing protein.	Uncharacterized protein.	0.999
PBRA_001576	PBRA_000447	A0A0G4IZ25	A0A0G4IHG8	Uncharacterized protein.	Beta-Casp domain-containing protein.	0.999
PBRA_001576	PBRA_001606	A0A0G4IZ25	A0A0G4IZ48	Uncharacterized protein.	RPOLD domain-containing protein.	0.846
PBRA_001576	PBRA_002235	A0A0G4IZ25	A0A0G4J318	Uncharacterized protein.	RPOL4c domain-containing protein.	0.835
PBRA_001576	PBRA_002688	A0A0G4IZ25	A0A0G4J636	Uncharacterized protein.	Uncharacterized protein.	0.837
PBRA_001576	PBRA_003327	A0A0G4IZ25	A0A0G4J835	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.929
PBRA_001576	PBRA_004384	A0A0G4IZ25	A0A0G4IKE6	Uncharacterized protein.	Uncharacterized protein.	0.774
PBRA_001576	PBRA_004859	A0A0G4IZ25	A0A0G4ILZ5	Uncharacterized protein.	Uncharacterized protein.	0.995
PBRA_001576	PBRA_005763	A0A0G4IZ25	A0A0G4IPU5	Uncharacterized protein.	Uncharacterized protein.	0.888
PBRA_001576	PBRA_005964	A0A0G4IZ25	A0A0G4IRF4	Uncharacterized protein.	Uncharacterized protein.	0.999
PBRA_001576	PBRA_008423	A0A0G4IZ25	A0A0G4J1G6	Uncharacterized protein.	Uncharacterized protein.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.87

expected number of edges:

15

PPI enrichment p-value:

0.736

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007224

Smoothened signaling pathway

3 of 65

2.26

1.85

0.00030

GO:0060271

Cilium assembly

4 of 513

1.49

1.15

0.0023

GO:0050794

Regulation of cellular process

9 of 11436

0.49

0.32

0.0367

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003746

Translation elongation factor activity

6 of 48

2.69

5.95

3.32e-12

GO:0008158

Hedgehog receptor activity

3 of 5

3.37

3.57

3.54e-07

GO:0003924

GTPase activity

6 of 562

1.63

2.29

9.25e-07

GO:0005525

GTP binding

6 of 783

1.48

1.87

5.61e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036038

MKS complex

4 of 24

2.82

3.93

5.12e-08

GO:0036064

Ciliary basal body

3 of 254

1.67

0.94

0.0123

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15917

MKS complex, and Tectonic

5 of 32

2.79

4.8

9.92e-10

CL:15920

MKS complex, and CC2D2A N-terminal C2 domain

4 of 25

2.8

3.86

6.72e-08

CL:18642

Synthesis of diphthamide-EEF2

3 of 18

2.82

2.64

1.46e-05

CL:15955

B9-type C2 domain, and Meckelin

2 of 6

3.12

1.6

0.0013

CL:18645

Peptidyl-diphthamide metabolic process, and Elongation factor G, domain III

2 of 13

2.78

1.3

0.0043

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156902

Peptide chain elongation

6 of 6

3.6

8.93

6.05e-17

MAP-5358493

Synthesis of diphthamide-EEF2

6 of 19

3.1

7.66

5.79e-15

MAP-156842

Eukaryotic Translation Elongation

6 of 19

3.1

7.66

5.79e-15

MAP-8876725

Protein methylation

6 of 36

2.82

6.85

8.56e-14

MAP-163841

Gamma carboxylation, hypusine formation and arylsulfatase activation

6 of 49

2.68

6.4

3.78e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031965

Nuclear membrane

6 of 101

2.37

4.86

1.22e-10

GOCC:0036038

MKS complex

4 of 16

2.99

4.51

4.95e-09

GOCC:0043226

Organelle

11 of 15654

0.44

0.36

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03144

Elongation factor Tu domain 2

6 of 25

2.98

6.91

1.14e-13

PF01926

50S ribosome-binding GTPase

6 of 87

2.44

5.08

5.86e-11

PF07162

Ciliary basal body-associated, B9 protein

4 of 9

3.24

4.82

1.66e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041095

Elongation Factor G, domain II

6 of 10

3.37

7.92

3.43e-15

IPR005517

Translation elongation factor EFG/EF2, domain IV

6 of 13

3.26

7.75

5.80e-15

IPR000640

Elongation factor EFG, domain V-like

6 of 14

3.23

7.73

5.80e-15

IPR035647

EF-G domain III/V-like

6 of 15

3.2

7.72

5.80e-15

IPR031157

Tr-type G domain, conserved site

6 of 21

3.05

7.3

2.53e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00889

Elongation factor G, domain IV

6 of 10

3.37

8.49

2.94e-16

SM00838

Elongation factor G C-terminus

6 of 14

3.23

8.21

7.10e-16

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