node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PBRA_001108 | PBRA_002943 | A0A0G4IVF5 | A0A0G4J6H0 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.902 |
PBRA_001108 | PBRA_003476 | A0A0G4IVF5 | A0A0G4J8Y6 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Uncharacterized protein. | 0.670 |
PBRA_001108 | PBRA_005559 | A0A0G4IVF5 | A0A0G4IP60 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.999 |
PBRA_001108 | PBRA_005570 | A0A0G4IVF5 | A0A0G4INY6 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.744 |
PBRA_001108 | PBRA_005963 | A0A0G4IVF5 | A0A0G4IRS1 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
PBRA_001108 | PBRA_006519 | A0A0G4IVF5 | A0A0G4IT12 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.897 |
PBRA_001108 | PBRA_007280 | A0A0G4IVF5 | A0A0G4IWB5 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Uncharacterized protein. | 0.918 |
PBRA_001108 | PBRA_008438 | A0A0G4IVF5 | A0A0G4J1H8 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.889 |
PBRA_001108 | PBRA_009356 | A0A0G4IVF5 | A0A0G4J6D6 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.812 |
PBRA_002094 | PBRA_002943 | A0A0G4J1G7 | A0A0G4J6H0 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.580 |
PBRA_002094 | PBRA_003476 | A0A0G4J1G7 | A0A0G4J8Y6 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Uncharacterized protein. | 0.565 |
PBRA_002094 | PBRA_005570 | A0A0G4J1G7 | A0A0G4INY6 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.991 |
PBRA_002094 | PBRA_006519 | A0A0G4J1G7 | A0A0G4IT12 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.856 |
PBRA_002094 | PBRA_007280 | A0A0G4J1G7 | A0A0G4IWB5 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Uncharacterized protein. | 0.857 |
PBRA_002094 | PBRA_009356 | A0A0G4J1G7 | A0A0G4J6D6 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.639 |
PBRA_002943 | PBRA_001108 | A0A0G4J6H0 | A0A0G4IVF5 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.902 |
PBRA_002943 | PBRA_002094 | A0A0G4J6H0 | A0A0G4J1G7 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.580 |
PBRA_002943 | PBRA_003476 | A0A0G4J6H0 | A0A0G4J8Y6 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Uncharacterized protein. | 0.918 |
PBRA_002943 | PBRA_005559 | A0A0G4J6H0 | A0A0G4IP60 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.910 |
PBRA_002943 | PBRA_005570 | A0A0G4J6H0 | A0A0G4INY6 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.700 |