PBRA_008310 protein (Plasmodiophora brassicae)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

PBRA_008310

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (399 aa)

Predicted Functional Partners:

PBRA_004454

0.684

PBRA_009621

0.625

PBRA_000836

0.620

PBRA_000473

0.572

PBRA_006363

0.572

PBRA_006693

0.572

PBRA_006751

0.572

PBRA_006987

0.572

PBRA_006871

0.572

PBRA_008425

0.572

Your Current Organism:

Plasmodiophora brassicae

NCBI taxonomy Id: 37360
Other names: P. brassicae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PBRA_000473	PBRA_000836	A0A0G4IHY6	A0A0G4IQT9	ANK_REP_REGION domain-containing protein.	Peptidase C51 domain-containing protein.	0.443
PBRA_000473	PBRA_006363	A0A0G4IHY6	A0A0G4ISY3	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_000473	PBRA_006693	A0A0G4IHY6	A0A0G4ITR4	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_000473	PBRA_006751	A0A0G4IHY6	A0A0G4ITV5	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_000473	PBRA_006871	A0A0G4IHY6	A0A0G4IU47	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_000473	PBRA_006987	A0A0G4IHY6	A0A0G4IU45	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_000473	PBRA_008310	A0A0G4IHY6	A0A0G4J040	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.572
PBRA_000473	PBRA_008425	A0A0G4IHY6	A0A0G4J0K1	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.646
PBRA_000473	PBRA_009621	A0A0G4IHY6	A0A0G4IIV8	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.472
PBRA_000836	PBRA_000473	A0A0G4IQT9	A0A0G4IHY6	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_006363	A0A0G4IQT9	A0A0G4ISY3	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_006693	A0A0G4IQT9	A0A0G4ITR4	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_006751	A0A0G4IQT9	A0A0G4ITV5	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_006871	A0A0G4IQT9	A0A0G4IU47	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_006987	A0A0G4IQT9	A0A0G4IU45	Peptidase C51 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.443
PBRA_000836	PBRA_008310	A0A0G4IQT9	A0A0G4J040	Peptidase C51 domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.620
PBRA_000836	PBRA_008425	A0A0G4IQT9	A0A0G4J0K1	Peptidase C51 domain-containing protein.	Uncharacterized protein.	0.443
PBRA_004454	PBRA_008310	A0A0G4IKF7	A0A0G4J040	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.684
PBRA_006363	PBRA_000473	A0A0G4ISY3	A0A0G4IHY6	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.646
PBRA_006363	PBRA_000836	A0A0G4ISY3	A0A0G4IQT9	ANK_REP_REGION domain-containing protein.	Peptidase C51 domain-containing protein.	0.443

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

28

PPI enrichment p-value:

1.36e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 159

1.09

0.96

0.00072

GO:0050794

Regulation of cellular process

10 of 494

0.82

0.78

2.77e-05

GO:0050896

Response to stimulus

8 of 364

0.86

0.75

0.00041

GO:0018106

Peptidyl-histidine phosphorylation

3 of 45

1.34

0.67

0.0352

GO:0000160

Phosphorelay signal transduction system

4 of 100

1.12

0.65

0.0233

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 232

0.93

0.59

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

10 of 766

0.63

0.54

0.00022

GO:0016020

Membrane

11 of 1107

0.51

0.44

0.00022

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2910

GGDEF domain, and Transducer

10 of 77

1.63

3.56

3.28e-13

CL:2916

GGDEF domain, and Transducer

9 of 66

1.65

3.46

4.60e-12

CL:2921

GGDEF domain, and Transmembrane signaling receptor activity

8 of 56

1.67

3.3

8.62e-11

CL:2930

GGDEF domain, and HPT domain superfamily

7 of 45

1.71

3.14

1.63e-09

CL:2937

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and EAL domain

6 of 35

1.75

2.9

3.45e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

8 of 333

0.9

0.85

8.34e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

5 of 79

1.32

1.21

0.00050

KW-0175

Coiled coil

6 of 368

0.73

0.43

0.0345

KW-0808

Transferase

7 of 578

0.6

0.37

0.0345

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000014

PAS domain

7 of 44

1.72

2.99

8.32e-09

IPR035965

PAS domain superfamily

7 of 50

1.66

2.8

1.51e-08

IPR029787

Nucleotide cyclase

8 of 69

1.58

2.68

6.62e-09

IPR000160

GGDEF domain

8 of 69

1.58

2.68

6.62e-09

IPR043128

Reverse transcriptase/Diguanylate cyclase domain

8 of 73

1.56

2.62

6.62e-09

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 29

1.83

3.17

1.55e-08

SM00267

Diguanylate cyclase

8 of 61

1.63

3.1

2.40e-10

SM00091

PAS domain

5 of 40

1.61

2.09

4.59e-06

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