STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)    
Predicted Functional Partners:
SIT18773.1
Glycine dehydrogenase; Belongs to the GcvP family.
  
 
 0.998
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 
 0.997
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase.
  
 0.989
SIT17892.1
Phosphoribosylformylglycinamidine synthase.
  
 
 0.982
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.981
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.973
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.973
SIT28135.1
L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.963
SIT21339.1
5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.952
SIS82527.1
Ribose 5-phosphate isomerase B.
 
 
  0.943
Your Current Organism:
Chryseobacterium gambrini
NCBI taxonomy Id: 373672
Other names: C. gambrini, CCUG 52549, Chryseobacterium gambrini Herzog et al. 2008 emend. Montero-Calasanz et al. 2014, Chryseobacterium sp. 5-1St1a, DSM 18014, strain 5-1St1a
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