Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AQQ59077.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)    
Predicted Functional Partners:
AQQ60128.1
Nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 0.991
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.978
nifS
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.799
AQQ59076.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.771
AQQ59075.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.684
AQQ59074.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.614
AQQ60265.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.573
AQQ58970.1
Methionine sulfoxide reductase A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.489
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
    
 0.455
hisI
phosphoribosyl-ATP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family.
  
    0.446
Your Current Organism:
Helicobacter bilis
NCBI taxonomy Id: 37372
Other names: ATCC 51630, CCUG 38995 B, CIP 104752, Flexispira rappini species 8, Flexispira taxon 9, H. bilis, Helicobacter sp. ATCC 43879, Helicobacter sp. ATCC 49314, Helicobacter sp. ATCC 49317, Helicobacter sp. ATCC 49320, strain Hb1
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