Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ureAUrease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the urease beta subunit family. (225 aa)    
Predicted Functional Partners:
ureC
Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
ureH
Urease accessory protein UreH; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.993
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.991
AQQ60219.1
Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family.
 
  
  0.934
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
  
 0.921
ureE
Urease accessory protein ureE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
 
  
 0.800
ispF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
    
   0.745
AQQ59921.1
Acid-activated urea channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.617
hypB
Hydrogenase nickel incorporation protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.559
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
     
 0.525
Your Current Organism:
Helicobacter bilis
NCBI taxonomy Id: 37372
Other names: ATCC 51630, CCUG 38995 B, CIP 104752, Flexispira rappini species 8, Flexispira taxon 9, H. bilis, Helicobacter sp. ATCC 43879, Helicobacter sp. ATCC 49314, Helicobacter sp. ATCC 49317, Helicobacter sp. ATCC 49320, strain Hb1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.