STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AQQ59921.1Acid-activated urea channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)    
Predicted Functional Partners:
ureE
Urease accessory protein ureE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
 
   
 0.938
ureC
Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.906
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
   
 0.863
ureH
Urease accessory protein UreH; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
   
 0.833
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
     
 0.811
ureA
Urease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the urease beta subunit family.
 
   
 0.651
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
      
 0.523
atpA
ATP F0F1 synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
      
 0.523
AQQ59786.1
Phosphoribosylanthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.523
mutY
Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.523
Your Current Organism:
Helicobacter bilis
NCBI taxonomy Id: 37372
Other names: ATCC 51630, CCUG 38995 B, CIP 104752, Flexispira rappini species 8, Flexispira taxon 9, H. bilis, Helicobacter sp. ATCC 43879, Helicobacter sp. ATCC 49314, Helicobacter sp. ATCC 49317, Helicobacter sp. ATCC 49320, strain Hb1
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