node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACL68851.1 | ACL68852.1 | Hore_00900 | Hore_00910 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | 0.638 |
ACL68851.1 | disA | Hore_00900 | Hore_00890 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 0.647 |
ACL68851.1 | ispD | Hore_00900 | Hore_00920 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.698 |
ACL68851.1 | ispF | Hore_00900 | Hore_00930 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.640 |
ACL68851.1 | radA | Hore_00900 | Hore_00880 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.640 |
ACL68851.1 | rpoA | Hore_00900 | Hore_01450 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.852 |
ACL68851.1 | rpoB | Hore_00900 | Hore_01090 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.881 |
ACL68851.1 | rpoC | Hore_00900 | Hore_01100 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.869 |
ACL68851.1 | rpoZ | Hore_00900 | Hore_09820 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.853 |
ACL68851.1 | sigA | Hore_00900 | Hore_12400 | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | RNA polymerase, sigma 70 subunit, RpoD family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.871 |
ACL68852.1 | ACL68851.1 | Hore_00910 | Hore_00900 | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | 0.638 |
ACL68852.1 | disA | Hore_00910 | Hore_00890 | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 0.654 |
ACL68852.1 | ispD | Hore_00910 | Hore_00920 | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.875 |
ACL68852.1 | ispF | Hore_00910 | Hore_00930 | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.824 |
ACL68852.1 | radA | Hore_00910 | Hore_00880 | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.739 |
disA | ACL68851.1 | Hore_00890 | Hore_00900 | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain. | 0.647 |
disA | ACL68852.1 | Hore_00890 | Hore_00910 | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | PilT protein domain protein; PFAM: PIN domain; TRAM domain. | 0.654 |
disA | ispD | Hore_00890 | Hore_00920 | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.623 |
disA | ispF | Hore_00890 | Hore_00930 | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.424 |
disA | radA | Hore_00890 | Hore_00880 | Predicted nucleic-acid-binding protein (contains the HHH domain); Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.969 |