STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa)    
Predicted Functional Partners:
ACL69559.1
PFAM: Homoserine dehydrogenase; ACT domain; Homoserine dehydrogenase, NAD binding domain.
 
 0.999
ACL69560.1
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.999
ACL69561.1
PFAM: Amino acid kinase family; ACT domain; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family.
  
 
 0.910
purM
Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal domain; AIR synthase related protein, N-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase.
 
    
 0.906
ACL70706.1
Homocysteine S-methyltransferase; PFAM: Pterin binding enzyme; B12 binding domain; B12 binding domain; Homocysteine S-methyltransferase; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain; 5-methyltetrahydrofolate--homocysteine methyltransferase.
    
 0.897
ACL70705.1
PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
  
 0.861
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.850
ACL71052.1
TIGRFAM: serine O-acetyltransferase.
     
 0.828
ACL70382.1
PFAM: Serine dehydratase alpha chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit.
  
 
 0.827
ACL70383.1
PFAM: ACT domain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit.
  
 
 0.827
Your Current Organism:
Halothermothrix orenii
NCBI taxonomy Id: 373903
Other names: H. orenii H 168, Halothermothrix orenii H 168, Halothermothrix orenii str. H 168, Halothermothrix orenii strain H 168
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.