| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCI_0386 | birA | BCI_0386 | BCI_0505 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.420 |
| BCI_0386 | guaA | BCI_0386 | BCI_0650 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.595 |
| BCI_0386 | lipA | BCI_0386 | BCI_0238 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.496 |
| aceF | birA | BCI_0511 | BCI_0505 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.443 |
| aceF | lipA | BCI_0511 | BCI_0238 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.490 |
| aceF | lipB | BCI_0511 | BCI_0237 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.492 |
| aceF | nfuA | BCI_0511 | BCI_0484 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | yhgI protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.476 |
| aceF | pta | BCI_0511 | BCI_0383 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.964 |
| birA | BCI_0386 | BCI_0505 | BCI_0386 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.420 |
| birA | aceF | BCI_0505 | BCI_0511 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF02817. | 0.443 |
| birA | guaA | BCI_0505 | BCI_0650 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.725 |
| birA | lipA | BCI_0505 | BCI_0238 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.437 |
| birA | lipB | BCI_0505 | BCI_0237 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.473 |
| birA | mrdB | BCI_0505 | BCI_0236 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.570 |
| birA | pta | BCI_0505 | BCI_0383 | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.566 |
| guaA | BCI_0386 | BCI_0650 | BCI_0386 | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.595 |
| guaA | birA | BCI_0650 | BCI_0505 | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | biotin-[acetyl-CoA-carboxylase] ligase; Identified by similarity to SP:P06709; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.725 |
| guaA | lipA | BCI_0650 | BCI_0238 | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.471 |
| guaA | mrdA | BCI_0650 | BCI_0235 | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.562 |
| guaA | mrdB | BCI_0650 | BCI_0236 | GMP synthetase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.437 |
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