Kcr_0608 protein (Korarchaeum cryptofilum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Kcr_0608

PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein. (895 aa)

Predicted Functional Partners:

cysS

0.900

Kcr_0606

0.645

Kcr_0607

0.645

Kcr_0605

0.463

Your Current Organism:

Korarchaeum cryptofilum

NCBI taxonomy Id: 374847
Other names: C. Korarchaeum cryptofilum OPF8, Candidatus Korarchaeum cryptofilum OPF8, Candidatus Korarchaeum cryptofilum str. OPF8, Candidatus Korarchaeum cryptofilum strain OPF8, Korarchaeum cryptofilum OPF8, korarchaeote OPF1-KOR

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kcr_0605	Kcr_0606	Kcr_0605	Kcr_0606	KEGG: deb:DehaBAV1_1212 hypothetical protein.	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	0.545
Kcr_0605	Kcr_0607	Kcr_0605	Kcr_0607	KEGG: deb:DehaBAV1_1212 hypothetical protein.	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	0.545
Kcr_0605	Kcr_0608	Kcr_0605	Kcr_0608	KEGG: deb:DehaBAV1_1212 hypothetical protein.	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	0.463
Kcr_0606	Kcr_0605	Kcr_0606	Kcr_0605	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	KEGG: deb:DehaBAV1_1212 hypothetical protein.	0.545
Kcr_0606	Kcr_0607	Kcr_0606	Kcr_0607	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	0.984
Kcr_0606	Kcr_0608	Kcr_0606	Kcr_0608	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	0.645
Kcr_0607	Kcr_0605	Kcr_0607	Kcr_0605	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	KEGG: deb:DehaBAV1_1212 hypothetical protein.	0.545
Kcr_0607	Kcr_0606	Kcr_0607	Kcr_0606	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	0.984
Kcr_0607	Kcr_0608	Kcr_0607	Kcr_0608	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	0.645
Kcr_0608	Kcr_0605	Kcr_0608	Kcr_0605	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	KEGG: deb:DehaBAV1_1212 hypothetical protein.	0.463
Kcr_0608	Kcr_0606	Kcr_0608	Kcr_0606	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: tpe:Tpen_1762 type III restriction enzyme, res subunit.	0.645
Kcr_0608	Kcr_0607	Kcr_0608	Kcr_0607	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	PFAM: protein of unknown function DUF790; KEGG: tpe:Tpen_1761 protein of unknown function DUF790.	0.645
Kcr_0608	cysS	Kcr_0608	Kcr_0947	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; KEGG: tko:TK0444 cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.900
cysS	Kcr_0608	Kcr_0947	Kcr_0608	TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; KEGG: tko:TK0444 cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	PFAM: TM1410 hypothetical-related protein; KEGG: gme:Gmet_1962 hypothetical protein.	0.900

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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