STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APG07244.1DNA topoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)    
Predicted Functional Partners:
APG06937.1
ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.779
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.766
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.766
APG09846.1
Ribonuclease HII; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.722
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.722
APG09114.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.699
APG09535.1
DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.687
APG09913.1
DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.684
APG15397.1
DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.680
APG08150.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.667
Your Current Organism:
Bradyrhizobium japonicum
NCBI taxonomy Id: 375
Other names: ATCC 10324, B. japonicum, Bradyrhizobium sp. BC-P14, Bradyrhizobium sp. SEMIA 511, Bradyrhizobium sp. SEMIA 6154, Bradyrhizobium sp. mas14, Bradyrhizobium sp. mas32, Bradyrhizobium sp. mas33, Bradyrhizobium sp. mas35, Bradyrhizobium sp. mas36, Bradyrhizobium sp. mas37, Bradyrhizobium sp. mas38, Bradyrhizobium sp. mas39, Bradyrhizobium sp. mas4, Bradyrhizobium sp. mas43, Bradyrhizobium sp. mas44, Bradyrhizobium sp. mas45, Bradyrhizobium sp. mas48, Bradyrhizobium sp. mas5, CCUG 27876, CIP 106093, DSM 30131, DSMZ 30131, HAMBI 2314, IFO 14783, JCM 20679, LMG 6138, LMG:6138, NBRC 14783, NRRL B-4507, NRRL L-241, Rhizobacterium japonicum, Rhizobium japonicum, USDA 6
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