ANK61341.1 protein (Lactobacillus backii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ANK61341.1

Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)

Predicted Functional Partners:

ANK61340.1

0.997

AYR53_00360

0.995

ANK63475.1

0.989

ANK62205.1

0.768

argH

0.627

argG

0.626

ANK62222.1

0.596

ANK62223.1

0.579

ANK63155.1

0.578

glnQ

0.576

Your Current Organism:

Lactobacillus backii

NCBI taxonomy Id: 375175
Other names: DSM 18080, JCM 18665, L. backii, LMG 23555, LMG:23555, Lactobacillus backi, Lactobacillus backii Tohno et al. 2013, strain L1062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK61340.1	ANK61341.1	AYR53_00365	AYR53_00370	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANK61340.1	ANK62205.1	AYR53_00365	AYR53_05105	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
ANK61340.1	ANK62222.1	AYR53_00365	AYR53_05210	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.540
ANK61340.1	ANK62223.1	AYR53_00365	AYR53_05215	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.524
ANK61340.1	ANK63155.1	AYR53_00365	AYR53_10500	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Polar amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
ANK61340.1	ANK63475.1	AYR53_00365	AYR53_00375	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANK61340.1	AYR53_00360	AYR53_00365	AYR53_00360	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.988
ANK61340.1	glnQ	AYR53_00365	AYR53_10145	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Similar to ATP-binding component of ABC transporters; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.957
ANK61341.1	ANK61340.1	AYR53_00370	AYR53_00365	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANK61341.1	ANK62205.1	AYR53_00370	AYR53_05105	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.768
ANK61341.1	ANK62222.1	AYR53_00370	AYR53_05210	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.596
ANK61341.1	ANK62223.1	AYR53_00370	AYR53_05215	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.579
ANK61341.1	ANK63155.1	AYR53_00370	AYR53_10500	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Polar amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.578
ANK61341.1	ANK63475.1	AYR53_00370	AYR53_00375	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
ANK61341.1	AYR53_00360	AYR53_00370	AYR53_00360	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
ANK61341.1	argG	AYR53_00370	AYR53_11320	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily.	0.626
ANK61341.1	argH	AYR53_00370	AYR53_11315	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.627
ANK61341.1	glnQ	AYR53_00370	AYR53_10145	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Similar to ATP-binding component of ABC transporters; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.576
ANK62205.1	ANK61340.1	AYR53_05105	AYR53_00365	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
ANK62205.1	ANK61341.1	AYR53_05105	AYR53_00370	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.768

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.934

expected number of edges:

11

PPI enrichment p-value:

1.52e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006378

mRNA polyadenylation

6 of 14

2.33

4.34

1.48e-09

GO:0006379

mRNA cleavage

4 of 15

2.13

2.34

2.16e-05

GO:0006303

Double-strand break repair via nonhomologous end joining

4 of 19

2.02

2.16

4.09e-05

GO:0071481

Cellular response to X-ray

2 of 2

2.7

1.33

0.0038

GO:0071480

Cellular response to gamma radiation

2 of 2

2.7

1.33

0.0038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003684

Damaged DNA binding

3 of 22

1.84

1.05

0.0087

GO:0003676

Nucleic acid binding

9 of 914

0.69

0.51

0.0050

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005849

mRNA cleavage factor complex

6 of 16

2.28

4.4

7.26e-10

GO:0005847

mRNA cleavage and polyadenylation specificity factor complex

5 of 13

2.29

3.68

3.85e-08

GO:0043564

Ku70:Ku80 complex

2 of 2

2.7

1.45

0.0023

GO:0140513

Nuclear protein-containing complex

10 of 622

0.91

0.98

9.84e-07

GO:0000785

Chromatin

6 of 288

1.02

0.86

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4200

mRNA polyadenylation, and PTW/PP1 phosphatase complex

6 of 17

2.25

4.29

1.09e-09

CL:2752

Non-homologous end-joining

4 of 5

2.6

3.43

3.34e-07

CL:4201

mRNA cleavage and polyadenylation specificity factor complex, and PTW/PP1 phosphatase complex

4 of 10

2.3

2.91

1.98e-06

CL:4204

Beta-Casp domain, and mRNA cleavage and polyadenylation specificity factor complex

2 of 5

2.3

1.11

0.0089

CL:4221

mRNA polyadenylation

2 of 6

2.22

1.06

0.0105

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03450

Non-homologous end-joining

4 of 11

2.26

3.07

7.83e-07

map03015

mRNA surveillance pathway

7 of 71

1.7

3.02

3.63e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77595

Processing of Intronless Pre-mRNAs

5 of 16

2.2

3.29

1.85e-07

MAP-75067

Processing of Capped Intronless Pre-mRNA

5 of 19

2.12

3.21

1.92e-07

MAP-73856

RNA Polymerase II Transcription Termination

3 of 26

1.76

1.1

0.0060

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 194

1.11

0.79

0.0060

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005849

mRNA cleavage factor complex

6 of 16

2.28

4.39

7.58e-10

GOCC:0005847

mRNA cleavage and polyadenylation specificity factor complex

5 of 12

2.32

3.76

2.91e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02735

Ku70/Ku80 beta-barrel domain

2 of 2

2.7

1.01

0.0146

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016194

SPOC-like, C-terminal domain superfamily

2 of 2

2.7

0.75

0.0435

IPR006164

Ku70/Ku80 beta-barrel domain

2 of 2

2.7

0.75

0.0435

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