| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hmgL | ilvB | mma_0124 | mma_2150 | hydroxymethylglutaryl-CoA lyase. | Acetolactate synthase large subunit. | 0.440 |
| hmgL | ilvC | mma_0124 | mma_2148 | hydroxymethylglutaryl-CoA lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.442 |
| hmgL | ilvH | mma_0124 | mma_2149 | hydroxymethylglutaryl-CoA lyase. | Acetolactate synthase small subunit. | 0.629 |
| hmgL | leuC1 | mma_0124 | mma_2172 | hydroxymethylglutaryl-CoA lyase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.666 |
| hmgL | leuC2 | mma_0124 | mma_2343 | hydroxymethylglutaryl-CoA lyase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.666 |
| hmgL | leuD1 | mma_0124 | mma_2170 | hydroxymethylglutaryl-CoA lyase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.650 |
| hmgL | leuD2 | mma_0124 | mma_2344 | hydroxymethylglutaryl-CoA lyase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.650 |
| hmgL | ttuC | mma_0124 | mma_1237 | hydroxymethylglutaryl-CoA lyase. | Tartrate dehydrogenase. | 0.643 |
| ilvB | hmgL | mma_2150 | mma_0124 | Acetolactate synthase large subunit. | hydroxymethylglutaryl-CoA lyase. | 0.440 |
| ilvB | ilvC | mma_2150 | mma_2148 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
| ilvB | ilvH | mma_2150 | mma_2149 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
| ilvB | leuA1 | mma_2150 | mma_2145 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.963 |
| ilvB | leuA2 | mma_2150 | mma_1198 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.903 |
| ilvB | leuC1 | mma_2150 | mma_2172 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.627 |
| ilvB | leuC2 | mma_2150 | mma_2343 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.684 |
| ilvB | leuD1 | mma_2150 | mma_2170 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.690 |
| ilvB | leuD2 | mma_2150 | mma_2344 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.764 |
| ilvB | ttuC | mma_2150 | mma_1237 | Acetolactate synthase large subunit. | Tartrate dehydrogenase. | 0.954 |
| ilvC | hmgL | mma_2148 | mma_0124 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | hydroxymethylglutaryl-CoA lyase. | 0.442 |
| ilvC | ilvB | mma_2148 | mma_2150 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase large subunit. | 0.998 |