| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| argJ | hisZ | mma_3004 | mma_2118 | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.414 |
| argJ | mma_3003 | mma_3004 | mma_3003 | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.703 |
| argJ | mutT | mma_3004 | mma_3002 | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | Mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | 0.579 |
| argJ | secA | mma_3004 | mma_3005 | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.614 |
| hisZ | argJ | mma_2118 | mma_3004 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.414 |
| hisZ | mma_3003 | mma_2118 | mma_3003 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.517 |
| hisZ | tyrA | mma_2118 | mma_2671 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | Prephenate dehydrogenase. | 0.520 |
| ilvC | mma_3003 | mma_2148 | mma_3003 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.529 |
| mma_3003 | argJ | mma_3003 | mma_3004 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.703 |
| mma_3003 | hisZ | mma_3003 | mma_2118 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.517 |
| mma_3003 | ilvC | mma_3003 | mma_2148 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.529 |
| mma_3003 | mutT | mma_3003 | mma_3002 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | Mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | 0.613 |
| mma_3003 | secA | mma_3003 | mma_3005 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.445 |
| mma_3003 | tyrA | mma_3003 | mma_2671 | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | Prephenate dehydrogenase. | 0.574 |
| mutT | argJ | mma_3002 | mma_3004 | Mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.579 |
| mutT | mma_3003 | mma_3002 | mma_3003 | Mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.613 |
| secA | argJ | mma_3005 | mma_3004 | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | Arginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.614 |
| secA | mma_3003 | mma_3005 | mma_3003 | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.445 |
| tyrA | hisZ | mma_2671 | mma_2118 | Prephenate dehydrogenase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.520 |
| tyrA | mma_3003 | mma_2671 | mma_3003 | Prephenate dehydrogenase. | Uncharacterized conserved protein; Predicted ATPase (AAA+ superfamily). | 0.574 |