| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gltB | hisA | mma_3301 | mma_3284 | Glutamate synthase (NADPH) large chain. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.633 |
| gltB | hisF1 | mma_3301 | mma_2270 | Glutamate synthase (NADPH) large chain. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.596 |
| gltB | hisF2 | mma_3301 | mma_3283 | Glutamate synthase (NADPH) large chain. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.596 |
| gltB | hisG | mma_3301 | mma_3289 | Glutamate synthase (NADPH) large chain. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.544 |
| gltB | hisI | mma_3301 | mma_3282 | Glutamate synthase (NADPH) large chain. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.628 |
| gltB | mma_3345 | mma_3301 | mma_3345 | Glutamate synthase (NADPH) large chain. | 4-hydroxybenzoate octaprenyltransferase; Belongs to the UbiA prenyltransferase family. | 0.616 |
| hisA | gltB | mma_3284 | mma_3301 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Glutamate synthase (NADPH) large chain. | 0.633 |
| hisA | hisF1 | mma_3284 | mma_2270 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.993 |
| hisA | hisF2 | mma_3284 | mma_3283 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
| hisA | hisG | mma_3284 | mma_3289 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.989 |
| hisA | hisI | mma_3284 | mma_3282 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
| hisA | hisZ | mma_3284 | mma_2118 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.941 |
| hisA | mma_3345 | mma_3284 | mma_3345 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 4-hydroxybenzoate octaprenyltransferase; Belongs to the UbiA prenyltransferase family. | 0.634 |
| hisF1 | gltB | mma_2270 | mma_3301 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Glutamate synthase (NADPH) large chain. | 0.596 |
| hisF1 | hisA | mma_2270 | mma_3284 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.993 |
| hisF1 | hisF2 | mma_2270 | mma_3283 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.910 |
| hisF1 | hisG | mma_2270 | mma_3289 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.968 |
| hisF1 | hisI | mma_2270 | mma_3282 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.981 |
| hisF1 | hisZ | mma_2270 | mma_2118 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.862 |
| hisF1 | mma_2281 | mma_2270 | mma_2281 | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Oxidoreductase. | 0.517 |