node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A1B0FDG9 | A0A1B0FGV5 | A0A1B0FDG9 | A0A1B0FGV5 | Pribosyltran domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.915 |
A0A1B0FDG9 | A0A1B0FNV5 | A0A1B0FDG9 | A0A1B0FNV5 | Pribosyltran domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.839 |
A0A1B0FDG9 | A0A1B0FP83 | A0A1B0FDG9 | A0A1B0FP83 | Pribosyltran domain-containing protein. | PfkB domain-containing protein. | 0.925 |
A0A1B0FDG9 | A0A1B0FR56 | A0A1B0FDG9 | A0A1B0FR56 | Pribosyltran domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.915 |
A0A1B0FDG9 | A0A1B0G4J7 | A0A1B0FDG9 | A0A1B0G4J7 | Pribosyltran domain-containing protein. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.911 |
A0A1B0FDG9 | A0A1B0GAH1 | A0A1B0FDG9 | A0A1B0GAH1 | Pribosyltran domain-containing protein. | Phosphodiesterase. | 0.828 |
A0A1B0FDG9 | A0A1B0GGF2 | A0A1B0FDG9 | A0A1B0GGF2 | Pribosyltran domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.891 |
A0A1B0FDG9 | Adk2 | A0A1B0FDG9 | D3TLM5 | Pribosyltran domain-containing protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.926 |
A0A1B0FDG9 | D3TLL2_GLOMM | A0A1B0FDG9 | D3TLL2 | Pribosyltran domain-containing protein. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.927 |
A0A1B0FDG9 | D3TS08_GLOMM | A0A1B0FDG9 | D3TS08 | Pribosyltran domain-containing protein. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.966 |
A0A1B0FGV5 | A0A1B0FDG9 | A0A1B0FGV5 | A0A1B0FDG9 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Pribosyltran domain-containing protein. | 0.915 |
A0A1B0FGV5 | A0A1B0FNV5 | A0A1B0FGV5 | A0A1B0FNV5 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.985 |
A0A1B0FGV5 | A0A1B0FP83 | A0A1B0FGV5 | A0A1B0FP83 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | PfkB domain-containing protein. | 0.641 |
A0A1B0FGV5 | A0A1B0G4J7 | A0A1B0FGV5 | A0A1B0G4J7 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.825 |
A0A1B0FGV5 | A0A1B0GGF2 | A0A1B0FGV5 | A0A1B0GGF2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.908 |
A0A1B0FGV5 | Adk2 | A0A1B0FGV5 | D3TLM5 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.633 |
A0A1B0FGV5 | D3TLL2_GLOMM | A0A1B0FGV5 | D3TLL2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.878 |
A0A1B0FGV5 | D3TS08_GLOMM | A0A1B0FGV5 | D3TS08 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.940 |
A0A1B0FNV5 | A0A1B0FDG9 | A0A1B0FNV5 | A0A1B0FDG9 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Pribosyltran domain-containing protein. | 0.839 |
A0A1B0FNV5 | A0A1B0FGV5 | A0A1B0FNV5 | A0A1B0FGV5 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.985 |