Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH3Notch receptor 3. (2167 aa)    
Predicted Functional Partners:
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.999
MAML3
Mastermind like transcriptional coactivator 3.
    
 0.998
NOTCH4
Notch receptor 4.
    
 0.997
JAG2
Jagged canonical Notch ligand 2.
    
 0.996
NOTCH1
Notch receptor 1.
   
 0.996
NOTCH2
Notch receptor 2.
    
 0.996
JAG1
Jagged canonical Notch ligand 1.
    
 0.995
ENSCAPP00000008995
annotation not available
    
 0.994
DLL1
Delta like canonical Notch ligand 1.
    
 0.992
NUMB
NUMB endocytic adaptor protein.
    
 0.986
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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