Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLK3Polo like kinase 3. (476 aa)    
Predicted Functional Partners:
FZR1
Fizzy and cell division cycle 20 related 1.
   
 0.991
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 0.991
CCNB2
Cyclin B2.
   
 0.989
CDC20
Cell division cycle 20.
   
 0.986
PLK1
Polo like kinase 1.
    
 0.982
KIF23
Kinesin family member 23.
   
 0.982
TP53
Tumor protein p53.
    
 0.976
WDR41
WD repeat domain 41.
   
 0.971
CDC25A
Cell division cycle 25A.
   
 0.967
ESPL1
Extra spindle pole bodies like 1, separase.
   
 0.966
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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