STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE1Spire type actin nucleation factor 1. (591 aa)    
Predicted Functional Partners:
FMN1
Formin 1.
    
 0.983
GRAP2
GRB2 related adaptor protein 2.
   
 0.931
GRB2
Growth factor receptor bound protein 2.
    
 0.920
LAT
Linker for activation of T cells.
    
 0.899
FYB1
FYN binding protein 1.
   
 0.793
PLCG2
Phospholipase C gamma 2.
    
 0.781
PLCG1
Phospholipase C gamma 1.
    
 0.781
VAV2
Vav guanine nucleotide exchange factor 2.
   
 0.773
VAV3
Vav guanine nucleotide exchange factor 3.
   
 0.773
SKAP1
Src kinase associated phosphoprotein 1.
    
 0.743
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.