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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCK1NCK adaptor protein 1. (372 aa)    
Predicted Functional Partners:
LCP2
Lymphocyte cytosolic protein 2.
    
 0.979
ITSN2
Intersectin 2.
     
0.979
ENSCAPP00000000244
annotation not available
    
 0.975
PAK2
P21 (RAC1) activated kinase 2.
    
 0.935
SHOC2
SHOC2 leucine rich repeat scaffold protein.
   
 0.928
NCK2
NCK adaptor protein 2.
  
 
0.922
PAK4
P21 (RAC1) activated kinase 4.
    
 0.913
PAK6
P21 (RAC1) activated kinase 6.
    
 0.913
WASL
WASP like actin nucleation promoting factor.
    
 0.891
NCKIPSD
NCK interacting protein with SH3 domain.
    
 0.888
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.