TYMS protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TYMS

Thymidylate synthetase. (300 aa)

Predicted Functional Partners:

ENSCAPP00000008979

0.996

TK1

0.988

ENSCAPP00000007180

0.986

DCTD

0.979

SHMT2

0.975

MTHFD2

0.972

MTHFR

0.971

GART

0.968

ENSCAPP00000018298

0.967

SHMT1

0.964

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCTD	ENSCAPP00000007180	ENSCAPP00000002979	ENSCAPP00000007180	dCMP deaminase.	annotation not available	0.967
DCTD	ENSCAPP00000008979	ENSCAPP00000002979	ENSCAPP00000008979	dCMP deaminase.	annotation not available	0.778
DCTD	ENSCAPP00000018298	ENSCAPP00000002979	ENSCAPP00000018298	dCMP deaminase.	annotation not available	0.959
DCTD	TK1	ENSCAPP00000002979	ENSCAPP00000000935	dCMP deaminase.	Thymidine kinase 1.	0.951
DCTD	TYMS	ENSCAPP00000002979	ENSCAPP00000001574	dCMP deaminase.	Thymidylate synthetase.	0.979
ENSCAPP00000007180	DCTD	ENSCAPP00000007180	ENSCAPP00000002979	annotation not available	dCMP deaminase.	0.967
ENSCAPP00000007180	ENSCAPP00000008979	ENSCAPP00000007180	ENSCAPP00000008979	annotation not available	annotation not available	0.791
ENSCAPP00000007180	ENSCAPP00000018298	ENSCAPP00000007180	ENSCAPP00000018298	annotation not available	annotation not available	0.956
ENSCAPP00000007180	GART	ENSCAPP00000007180	ENSCAPP00000003834	annotation not available	annotation not available	0.572
ENSCAPP00000007180	SHMT1	ENSCAPP00000007180	ENSCAPP00000010725	annotation not available	Serine hydroxymethyltransferase 1.	0.413
ENSCAPP00000007180	SHMT2	ENSCAPP00000007180	ENSCAPP00000013335	annotation not available	Serine hydroxymethyltransferase 2.	0.413
ENSCAPP00000007180	TK1	ENSCAPP00000007180	ENSCAPP00000000935	annotation not available	Thymidine kinase 1.	0.964
ENSCAPP00000007180	TYMS	ENSCAPP00000007180	ENSCAPP00000001574	annotation not available	Thymidylate synthetase.	0.986
ENSCAPP00000008979	DCTD	ENSCAPP00000008979	ENSCAPP00000002979	annotation not available	dCMP deaminase.	0.778
ENSCAPP00000008979	ENSCAPP00000007180	ENSCAPP00000008979	ENSCAPP00000007180	annotation not available	annotation not available	0.791
ENSCAPP00000008979	ENSCAPP00000018298	ENSCAPP00000008979	ENSCAPP00000018298	annotation not available	annotation not available	0.689
ENSCAPP00000008979	GART	ENSCAPP00000008979	ENSCAPP00000003834	annotation not available	annotation not available	0.967
ENSCAPP00000008979	MTHFD2	ENSCAPP00000008979	ENSCAPP00000015442	annotation not available	annotation not available	0.900
ENSCAPP00000008979	MTHFR	ENSCAPP00000008979	ENSCAPP00000002096	annotation not available	Methylenetetrahydrofolate reductase.	0.928
ENSCAPP00000008979	SHMT1	ENSCAPP00000008979	ENSCAPP00000010725	annotation not available	Serine hydroxymethyltransferase 1.	0.969