ESAM protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ESAM

Endothelial cell adhesion molecule. (367 aa)

Predicted Functional Partners:

CLDN12

0.937

CLDN9

0.924

CLDN18

0.921

CLDN15

0.918

CLDN1

0.915

CLDN4

0.913

CLDN17

0.912

CLDN8

0.912

CLDN11

0.912

CLDN10

0.912

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

Export your current network:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN1	CLDN10	ENSCAPP00000013318	ENSCAPP00000008489	Claudin 1.	Claudin 10.	0.911
CLDN1	CLDN11	ENSCAPP00000013318	ENSCAPP00000005577	Claudin 1.	Claudin 11.	0.911
CLDN1	CLDN12	ENSCAPP00000013318	ENSCAPP00000011062	Claudin 1.	Claudin 12.	0.971
CLDN1	CLDN15	ENSCAPP00000013318	ENSCAPP00000017038	Claudin 1.	Claudin 15.	0.911
CLDN1	CLDN17	ENSCAPP00000013318	ENSCAPP00000004132	Claudin 1.	Claudin 17.	0.911
CLDN1	CLDN18	ENSCAPP00000013318	ENSCAPP00000008887	Claudin 1.	Claudin 18.	0.923
CLDN1	CLDN4	ENSCAPP00000013318	ENSCAPP00000002742	Claudin 1.	Claudin 4.	0.929
CLDN1	CLDN8	ENSCAPP00000013318	ENSCAPP00000004992	Claudin 1.	Claudin 8.	0.912
CLDN1	CLDN9	ENSCAPP00000013318	ENSCAPP00000005869	Claudin 1.	Claudin 9.	0.921
CLDN1	ESAM	ENSCAPP00000013318	ENSCAPP00000001736	Claudin 1.	Endothelial cell adhesion molecule.	0.915
CLDN10	CLDN1	ENSCAPP00000008489	ENSCAPP00000013318	Claudin 10.	Claudin 1.	0.911
CLDN10	CLDN11	ENSCAPP00000008489	ENSCAPP00000005577	Claudin 10.	Claudin 11.	0.912
CLDN10	CLDN12	ENSCAPP00000008489	ENSCAPP00000011062	Claudin 10.	Claudin 12.	0.959
CLDN10	CLDN15	ENSCAPP00000008489	ENSCAPP00000017038	Claudin 10.	Claudin 15.	0.911
CLDN10	CLDN17	ENSCAPP00000008489	ENSCAPP00000004132	Claudin 10.	Claudin 17.	0.911
CLDN10	CLDN18	ENSCAPP00000008489	ENSCAPP00000008887	Claudin 10.	Claudin 18.	0.919
CLDN10	CLDN4	ENSCAPP00000008489	ENSCAPP00000002742	Claudin 10.	Claudin 4.	0.911
CLDN10	CLDN8	ENSCAPP00000008489	ENSCAPP00000004992	Claudin 10.	Claudin 8.	0.941
CLDN10	CLDN9	ENSCAPP00000008489	ENSCAPP00000005869	Claudin 10.	Claudin 9.	0.916
CLDN10	ESAM	ENSCAPP00000008489	ENSCAPP00000001736	Claudin 10.	Endothelial cell adhesion molecule.	0.912