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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTHFRMethylenetetrahydrofolate reductase. (689 aa)    
Predicted Functional Partners:
CTH
Cystathionine gamma-lyase.
  
 0.991
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase.
  
 
 0.987
SHMT1
Serine hydroxymethyltransferase 1.
  
 
 0.971
SHMT2
Serine hydroxymethyltransferase 2.
  
 
 0.971
MTHFD1
Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.
  
 
 0.964
ENSCAPP00000009451
annotation not available
  
 
 0.963
BHMT
Betaine--homocysteine S-methyltransferase.
  
 
 0.961
MAT1A
Methionine adenosyltransferase 1A.
  
 
 0.955
MAT2A
Methionine adenosyltransferase 2A.
  
 
 0.955
BHMT2
Betaine--homocysteine S-methyltransferase 2.
  
 
 0.951
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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