Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
MTHFRMethylenetetrahydrofolate reductase. (689 aa)    
Predicted Functional Partners:
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase.
  
 
 0.996
MTHFD1
Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.
  
 0.981
SHMT1
Serine hydroxymethyltransferase 1.
  
 
 0.980
CTH
Cystathionine gamma-lyase.
  
 0.972
TYMS
Thymidylate synthetase.
    
 0.971
SHMT2
Serine hydroxymethyltransferase 2.
  
 
 0.971
DMGDH
Dimethylglycine dehydrogenase.
  
 
 0.969
GLDC
Glycine decarboxylase.
    
 0.965
ENSCAPP00000009451
annotation not available
  
 
 0.957
MTHFD2
annotation not available
    
 0.957
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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