Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (621 aa)    
Predicted Functional Partners:
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.983
NCK2
NCK adaptor protein 2.
    
   0.958
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta.
    
 0.949
PIK3CD
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta.
    
 0.942
ENSCAPP00000003122
annotation not available
    
 0.942
ENSCAPP00000015345
annotation not available
    
 0.942
PIK3CA
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.
    
 0.938
SYK
Spleen associated tyrosine kinase.
   
 0.936
GRB2
Growth factor receptor bound protein 2.
    
  0.933
ZAP70
Zeta chain of T cell receptor associated protein kinase 70.
   
 0.876
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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