Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FRS2Fibroblast growth factor receptor substrate 2. (486 aa)    
Predicted Functional Partners:
FGFR1
Fibroblast growth factor receptor 1.
    
 0.998
GRB2
Growth factor receptor bound protein 2.
    
 0.998
PTPN11
Protein tyrosine phosphatase non-receptor type 11.
    
 0.997
NTRK1
Neurotrophic receptor tyrosine kinase 1.
    
 0.993
FGFR2
Fibroblast growth factor receptor 2.
    
 0.991
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.984
NTRK2
Neurotrophic receptor tyrosine kinase 2.
    
 0.972
ENSCAPP00000013675
annotation not available
    
 0.961
CRK
CRK proto-oncogene, adaptor protein.
    
 0.956
FGFR4
Fibroblast growth factor receptor 4.
    
 0.954
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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