GHR protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GHR

Growth hormone receptor. (564 aa)

Predicted Functional Partners:

JAK2

0.998

ENSCAPP00000006307

0.994

JAK3

0.991

SOCS2

0.989

JAK1

0.970

ENSCAPP00000013807

0.968

ENSCAPP00000014725

0.968

PTPN11

0.958

TYK2

0.949

STAT3

0.947

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAPP00000006307	ENSCAPP00000013807	ENSCAPP00000006307	ENSCAPP00000013807	annotation not available	annotation not available	0.438
ENSCAPP00000006307	ENSCAPP00000014725	ENSCAPP00000006307	ENSCAPP00000014725	annotation not available	annotation not available	0.438
ENSCAPP00000006307	GHR	ENSCAPP00000006307	ENSCAPP00000002432	annotation not available	Growth hormone receptor.	0.994
ENSCAPP00000006307	JAK1	ENSCAPP00000006307	ENSCAPP00000001424	annotation not available	Janus kinase 1.	0.912
ENSCAPP00000006307	JAK2	ENSCAPP00000006307	ENSCAPP00000015682	annotation not available	Janus kinase 2.	0.921
ENSCAPP00000006307	JAK3	ENSCAPP00000006307	ENSCAPP00000012186	annotation not available	Janus kinase 3.	0.916
ENSCAPP00000006307	PTPN11	ENSCAPP00000006307	ENSCAPP00000013698	annotation not available	Protein tyrosine phosphatase non-receptor type 11.	0.476
ENSCAPP00000006307	SOCS2	ENSCAPP00000006307	ENSCAPP00000013927	annotation not available	Suppressor of cytokine signaling 2.	0.479
ENSCAPP00000006307	TYK2	ENSCAPP00000006307	ENSCAPP00000003485	annotation not available	Tyrosine kinase 2.	0.850
ENSCAPP00000013807	ENSCAPP00000006307	ENSCAPP00000013807	ENSCAPP00000006307	annotation not available	annotation not available	0.438
ENSCAPP00000013807	ENSCAPP00000014725	ENSCAPP00000013807	ENSCAPP00000014725	annotation not available	annotation not available	0.843
ENSCAPP00000013807	GHR	ENSCAPP00000013807	ENSCAPP00000002432	annotation not available	Growth hormone receptor.	0.968
ENSCAPP00000013807	JAK1	ENSCAPP00000013807	ENSCAPP00000001424	annotation not available	Janus kinase 1.	0.955
ENSCAPP00000013807	JAK2	ENSCAPP00000013807	ENSCAPP00000015682	annotation not available	Janus kinase 2.	0.990
ENSCAPP00000013807	JAK3	ENSCAPP00000013807	ENSCAPP00000012186	annotation not available	Janus kinase 3.	0.965
ENSCAPP00000013807	PTPN11	ENSCAPP00000013807	ENSCAPP00000013698	annotation not available	Protein tyrosine phosphatase non-receptor type 11.	0.775
ENSCAPP00000013807	SOCS2	ENSCAPP00000013807	ENSCAPP00000013927	annotation not available	Suppressor of cytokine signaling 2.	0.916
ENSCAPP00000013807	STAT3	ENSCAPP00000013807	ENSCAPP00000015472	annotation not available	Signal transducer and activator of transcription 3.	0.901
ENSCAPP00000013807	TYK2	ENSCAPP00000013807	ENSCAPP00000003485	annotation not available	Tyrosine kinase 2.	0.948
ENSCAPP00000014725	ENSCAPP00000006307	ENSCAPP00000014725	ENSCAPP00000006307	annotation not available	annotation not available	0.438