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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATF4Activating transcription factor 4. (332 aa)    
Predicted Functional Partners:
DDIT3
DNA damage inducible transcript 3.
   
 0.983
ENSCAPP00000009603
annotation not available
   
 0.964
EIF2AK3
Eukaryotic translation initiation factor 2 alpha kinase 3.
     
 0.957
EIF2S1
Eukaryotic translation initiation factor 2 subunit alpha.
     
 0.957
CREB1
cAMP responsive element binding protein 1.
    
 0.955
ATF6B
Activating transcription factor 6 beta.
     
 0.951
ENSCAPP00000004857
annotation not available
    
 0.936
CAMK4
Calcium/calmodulin dependent protein kinase IV.
   
  0.928
EP300
E1A binding protein p300.
    
 0.925
CREBBP
CREB binding protein.
    
 0.922
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.