STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP2BDNA topoisomerase II beta. (1336 aa)    
Predicted Functional Partners:
TOP1MT
DNA topoisomerase I mitochondrial.
   
 
 0.921
SMC2
Structural maintenance of chromosomes 2.
   
 
 0.903
SPO11
SPO11 initiator of meiotic double stranded breaks.
    
 0.902
TOP1
DNA topoisomerase I.
   
 
 0.901
TOP2A
DNA topoisomerase II alpha.
  
 
0.887
ENSCAPP00000018369
annotation not available
   
 
 0.866
ENSCAPP00000007915
annotation not available
   
 
 0.863
ENSCAPP00000013457
annotation not available
    
 0.853
UBE2C
Ubiquitin conjugating enzyme E2 C.
   
 0.846
SUMO1
Small ubiquitin like modifier 1.
    
 0.835
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
Server load: medium (76%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.