Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOP2BDNA topoisomerase II beta. (1336 aa)    
Predicted Functional Partners:
TOP2A
DNA topoisomerase II alpha.
   
  0.999
CDK1
Cyclin dependent kinase 1.
   
 
 0.951
TOP3B
DNA topoisomerase III beta.
   
  
 0.949
TOP1
DNA topoisomerase I.
   
 
 0.948
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4.
   
 
 0.911
TOP1MT
DNA topoisomerase I mitochondrial.
   
 
 0.911
SMC6
Structural maintenance of chromosomes 6.
   
 
 0.908
CCNB2
Cyclin B2.
   
  
 0.902
SMC2
Structural maintenance of chromosomes 2.
   
 
 0.875
PLK1
Polo like kinase 1.
   
 
 0.873
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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