Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (335 aa)    
Predicted Functional Partners:
PKIA
cAMP-dependent protein kinase inhibitor alpha.
   
 0.999
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.998
ENSCAPP00000013831
annotation not available
   
 0.997
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.995
RYR2
Ryanodine receptor 2.
    
 0.992
CACNA1C
Calcium voltage-gated channel subunit alpha1 C.
    
 0.988
SMO
Smoothened, frizzled class receptor.
    
 0.986
PLN
Phospholamban.
    
 0.984
CREB1
cAMP responsive element binding protein 1.
    
 0.983
ENSCAPP00000015456
annotation not available
    
 0.976
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.