Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1. (701 aa)    
Predicted Functional Partners:
MAP3K11
Mitogen-activated protein kinase kinase kinase 11.
    
 0.974
CRKL
CRK like proto-oncogene, adaptor protein.
    
 
 0.972
NCK1
NCK adaptor protein 1.
    
 
 0.961
GRB2
Growth factor receptor bound protein 2.
    
 
 0.961
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.959
EGFR
Epidermal growth factor receptor.
    
   0.957
LCP2
Lymphocyte cytosolic protein 2.
    
 
 0.940
GRAP2
GRB2 related adaptor protein 2.
   
 
 0.937
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 0.927
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
    
 0.919
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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