Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PCSK9Proprotein convertase subtilisin/kexin type 9. (620 aa)    
Predicted Functional Partners:
LDLR
Low density lipoprotein receptor.
    
 0.992
VLDLR
Very low density lipoprotein receptor.
    
 0.987
LRP8
LDL receptor related protein 8.
    
 0.971
PI4KA
Phosphatidylinositol 4-kinase alpha.
    
 0.965
SPTLC1
Serine palmitoyltransferase long chain base subunit 1.
   
 0.949
PCSK2
Proprotein convertase subtilisin/kexin type 2.
      
 0.949
PCSK1
Proprotein convertase subtilisin/kexin type 1.
      
 0.944
ENSCAPP00000017001
annotation not available
    
 0.928
FAM20C
FAM20C golgi associated secretory pathway kinase.
    
 0.905
EGF
Epidermal growth factor.
    
 0.880
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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