TIMP3 protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TIMP3

TIMP metallopeptidase inhibitor 3. (202 aa)

Predicted Functional Partners:

ENSCAPP00000017228

0.957

MMP2

0.956

ADAM17

0.955

MMP15

0.869

MMP7

0.868

MMP3

0.867

MMP13

0.850

MMP12

0.841

MMP14

0.841

ENSCAPP00000001035

0.833

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	TIMP3	ENSCAPP00000003538	ENSCAPP00000003644	ADAM metallopeptidase domain 17.	TIMP metallopeptidase inhibitor 3.	0.955
ENSCAPP00000001035	ENSCAPP00000017228	ENSCAPP00000001035	ENSCAPP00000017228	annotation not available	annotation not available	0.928
ENSCAPP00000001035	MMP12	ENSCAPP00000001035	ENSCAPP00000000179	annotation not available	Matrix metallopeptidase 12.	0.640
ENSCAPP00000001035	MMP13	ENSCAPP00000001035	ENSCAPP00000007650	annotation not available	Matrix metallopeptidase 13.	0.594
ENSCAPP00000001035	MMP14	ENSCAPP00000001035	ENSCAPP00000008296	annotation not available	Matrix metallopeptidase 14.	0.583
ENSCAPP00000001035	MMP15	ENSCAPP00000001035	ENSCAPP00000005616	annotation not available	Matrix metallopeptidase 15.	0.556
ENSCAPP00000001035	MMP2	ENSCAPP00000001035	ENSCAPP00000003871	annotation not available	Matrix metallopeptidase 2.	0.624
ENSCAPP00000001035	MMP3	ENSCAPP00000001035	ENSCAPP00000003986	annotation not available	Matrix metallopeptidase 3.	0.647
ENSCAPP00000001035	MMP7	ENSCAPP00000001035	ENSCAPP00000016727	annotation not available	Matrix metallopeptidase 7.	0.650
ENSCAPP00000001035	TIMP3	ENSCAPP00000001035	ENSCAPP00000003644	annotation not available	TIMP metallopeptidase inhibitor 3.	0.833
ENSCAPP00000017228	ENSCAPP00000001035	ENSCAPP00000017228	ENSCAPP00000001035	annotation not available	annotation not available	0.928
ENSCAPP00000017228	MMP12	ENSCAPP00000017228	ENSCAPP00000000179	annotation not available	Matrix metallopeptidase 12.	0.679
ENSCAPP00000017228	MMP13	ENSCAPP00000017228	ENSCAPP00000007650	annotation not available	Matrix metallopeptidase 13.	0.729
ENSCAPP00000017228	MMP14	ENSCAPP00000017228	ENSCAPP00000008296	annotation not available	Matrix metallopeptidase 14.	0.602
ENSCAPP00000017228	MMP15	ENSCAPP00000017228	ENSCAPP00000005616	annotation not available	Matrix metallopeptidase 15.	0.451
ENSCAPP00000017228	MMP2	ENSCAPP00000017228	ENSCAPP00000003871	annotation not available	Matrix metallopeptidase 2.	0.924
ENSCAPP00000017228	MMP3	ENSCAPP00000017228	ENSCAPP00000003986	annotation not available	Matrix metallopeptidase 3.	0.972
ENSCAPP00000017228	MMP7	ENSCAPP00000017228	ENSCAPP00000016727	annotation not available	Matrix metallopeptidase 7.	0.735
ENSCAPP00000017228	TIMP3	ENSCAPP00000017228	ENSCAPP00000003644	annotation not available	TIMP metallopeptidase inhibitor 3.	0.957
MMP12	ENSCAPP00000001035	ENSCAPP00000000179	ENSCAPP00000001035	Matrix metallopeptidase 12.	annotation not available	0.640