Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RETRet proto-oncogene. (1067 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha 1.
    
 0.999
GRB2
Growth factor receptor bound protein 2.
    
 0.996
GFRA2
GDNF family receptor alpha 2.
    
 0.996
EGFR
Epidermal growth factor receptor.
    
 0.993
PLCG1
Phospholipase C gamma 1.
    
 0.990
NCOA4
Nuclear receptor coactivator 4.
     
 0.978
SHC1
SHC adaptor protein 1.
    
 0.978
ERBB2
Erb-b2 receptor tyrosine kinase 2.
    
 0.974
STAT3
Signal transducer and activator of transcription 3.
    
 0.972
PSPN
Persephin.
     
 0.970
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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