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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.912
ENSCAPP00000013675
annotation not available
    
 0.874
CBLB
Cbl proto-oncogene B.
    
 0.860
CBLC
Cbl proto-oncogene C.
    
 0.859
GRAP2
GRB2 related adaptor protein 2.
    
 0.765
GRAP
GRB2 related adaptor protein.
    
 0.765
RASA3
RAS p21 protein activator 3.
    
  0.713
RASA2
RAS p21 protein activator 2.
    
  0.713
SPRY1
Sprouty RTK signaling antagonist 1.
   
0.654
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.650
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.