Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NCSTNNicastrin. (628 aa)    
Predicted Functional Partners:
PSEN1
Presenilin 1.
   
 0.999
PSEN2
Presenilin 2.
   
 0.999
NOTCH1
Notch receptor 1.
    
 0.988
TMED10
Transmembrane p24 trafficking protein 10.
    
 0.987
APP
Amyloid beta precursor protein.
    
 0.982
NOTCH2
Notch receptor 2.
    
 0.961
NOTCH4
Notch receptor 4.
    
 0.960
NOTCH3
Notch receptor 3.
    
 0.959
APLP2
Amyloid beta precursor like protein 2.
    
 0.867
ADAM10
ADAM metallopeptidase domain 10.
    
 
 0.848
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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