STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECTD2HECT domain E3 ubiquitin protein ligase 2. (541 aa)    
Predicted Functional Partners:
TP53
Tumor protein p53.
    
 0.802
UBE2L6
Ubiquitin conjugating enzyme E2 L6.
   
 0.752
ISG15
ISG15 ubiquitin like modifier.
   
 0.721
TRIP12
Thyroid hormone receptor interactor 12.
     
 0.709
TSC2
TSC complex subunit 2.
    
 0.679
RAD23A
RAD23 homolog A, nucleotide excision repair protein.
    
 0.652
ENSCAPP00000004243
annotation not available
   
 0.625
OASL
2'-5'-oligoadenylate synthetase like.
   
 0.625
ENSCAPP00000007736
annotation not available
    
 0.619
TP73
Tumor protein p73.
    
 0.619
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.