Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HECTD2HECT domain E3 ubiquitin protein ligase 2. (541 aa)    
Predicted Functional Partners:
TP53
Tumor protein p53.
    
 0.840
UBE2L6
Ubiquitin conjugating enzyme E2 L6.
   
 0.806
TSC2
TSC complex subunit 2.
    
 0.769
ENSCAPP00000005307
annotation not available
    
 
 0.723
TSC1
TSC complex subunit 1.
    
 0.704
ENSCAPP00000016912
annotation not available
   
 
 0.704
ENSCAPP00000017887
annotation not available
    
 0.690
ENSCAPP00000008920
annotation not available
    
  0.680
ENSCAPP00000011914
annotation not available
     
  0.677
ISG15
ISG15 ubiquitin like modifier.
   
 0.659
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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