Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (978 aa)    
Predicted Functional Partners:
HCN1
Hyperpolarization activated cyclic nucleotide gated potassium channel 1.
   
  0.992
HCN3
Hyperpolarization activated cyclic nucleotide gated potassium channel 3.
    
 0.961
HCN2
Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2.
    
 0.957
ENSCAPP00000005805
annotation not available
    
 0.835
SCN2A
Sodium voltage-gated channel alpha subunit 2.
    
 0.835
KCNE2
Potassium voltage-gated channel subfamily E regulatory subunit 2.
    
 0.780
SCN5A
Sodium voltage-gated channel alpha subunit 5.
    
 0.776
CACNA1C
Calcium voltage-gated channel subunit alpha1 C.
    
 0.653
CACNA1D
Calcium voltage-gated channel subunit alpha1 D.
    
 0.626
KCNJ2
Potassium inwardly rectifying channel subfamily J member 2.
     
 0.608
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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