Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SMPD2Sphingomyelin phosphodiesterase 2. (350 aa)    
Predicted Functional Partners:
SMPD3
Sphingomyelin phosphodiesterase 3.
     
 0.990
SMPD4
Sphingomyelin phosphodiesterase 4.
     
 0.982
SMPD1
Sphingomyelin phosphodiesterase 1.
     
 0.979
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.972
NSMAF
Neutral sphingomyelinase activation associated factor.
     
 0.968
SGMS2
Sphingomyelin synthase 2.
     
 0.966
DEGS1
Delta 4-desaturase, sphingolipid 1.
     
 0.960
ASAH2
N-acylsphingosine amidohydrolase 2.
     
 0.959
ACER2
Alkaline ceramidase 2.
    
 0.959
ASAH1
N-acylsphingosine amidohydrolase 1.
     
 0.956
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.