TLK1 protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TLK1

Tousled like kinase 1. (534 aa)

Predicted Functional Partners:

TLK2

0.944

ASF1B

0.848

ASF1A

0.845

CABIN1

0.585

ENSCAPP00000009178

0.578

ENSCAPP00000000279

0.529

YTHDC2

0.489

DYNLL2

0.478

RAD9A

0.472

HIRA

0.452

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASF1A	ASF1B	ENSCAPP00000005345	ENSCAPP00000004210	Anti-silencing function 1A histone chaperone.	Anti-silencing function 1B histone chaperone.	0.634
ASF1A	CABIN1	ENSCAPP00000005345	ENSCAPP00000004420	Anti-silencing function 1A histone chaperone.	Calcineurin binding protein 1.	0.954
ASF1A	HIRA	ENSCAPP00000005345	ENSCAPP00000002369	Anti-silencing function 1A histone chaperone.	Histone cell cycle regulator.	0.987
ASF1A	TLK1	ENSCAPP00000005345	ENSCAPP00000006362	Anti-silencing function 1A histone chaperone.	Tousled like kinase 1.	0.845
ASF1A	TLK2	ENSCAPP00000005345	ENSCAPP00000005910	Anti-silencing function 1A histone chaperone.	Tousled like kinase 2.	0.958
ASF1B	ASF1A	ENSCAPP00000004210	ENSCAPP00000005345	Anti-silencing function 1B histone chaperone.	Anti-silencing function 1A histone chaperone.	0.634
ASF1B	CABIN1	ENSCAPP00000004210	ENSCAPP00000004420	Anti-silencing function 1B histone chaperone.	Calcineurin binding protein 1.	0.879
ASF1B	HIRA	ENSCAPP00000004210	ENSCAPP00000002369	Anti-silencing function 1B histone chaperone.	Histone cell cycle regulator.	0.976
ASF1B	TLK1	ENSCAPP00000004210	ENSCAPP00000006362	Anti-silencing function 1B histone chaperone.	Tousled like kinase 1.	0.848
ASF1B	TLK2	ENSCAPP00000004210	ENSCAPP00000005910	Anti-silencing function 1B histone chaperone.	Tousled like kinase 2.	0.842
CABIN1	ASF1A	ENSCAPP00000004420	ENSCAPP00000005345	Calcineurin binding protein 1.	Anti-silencing function 1A histone chaperone.	0.954
CABIN1	ASF1B	ENSCAPP00000004420	ENSCAPP00000004210	Calcineurin binding protein 1.	Anti-silencing function 1B histone chaperone.	0.879
CABIN1	HIRA	ENSCAPP00000004420	ENSCAPP00000002369	Calcineurin binding protein 1.	Histone cell cycle regulator.	0.965
CABIN1	TLK1	ENSCAPP00000004420	ENSCAPP00000006362	Calcineurin binding protein 1.	Tousled like kinase 1.	0.585
CABIN1	TLK2	ENSCAPP00000004420	ENSCAPP00000005910	Calcineurin binding protein 1.	Tousled like kinase 2.	0.645
DYNLL2	TLK1	ENSCAPP00000017306	ENSCAPP00000006362	Dynein light chain LC8-type 2.	Tousled like kinase 1.	0.478
DYNLL2	TLK2	ENSCAPP00000017306	ENSCAPP00000005910	Dynein light chain LC8-type 2.	Tousled like kinase 2.	0.491
ENSCAPP00000000279	TLK1	ENSCAPP00000000279	ENSCAPP00000006362	annotation not available	Tousled like kinase 1.	0.529
ENSCAPP00000000279	TLK2	ENSCAPP00000000279	ENSCAPP00000005910	annotation not available	Tousled like kinase 2.	0.480
ENSCAPP00000009178	TLK1	ENSCAPP00000009178	ENSCAPP00000006362	annotation not available	Tousled like kinase 1.	0.578