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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNPPurine nucleoside phosphorylase. (240 aa)    
Predicted Functional Partners:
APRT
Adenine phosphoribosyltransferase.
  
 
 0.967
GDA
Guanine deaminase.
  
 
 0.962
ADK
Adenosine kinase.
    
 0.961
UPP2
Uridine phosphorylase 2.
    
 0.959
NMRK1
Nicotinamide riboside kinase 1.
   
 0.951
UPP1
Uridine phosphorylase 1.
    
 0.947
NAPRT
Nicotinate phosphoribosyltransferase.
    
 0.943
NT5E
5'-nucleotidase ecto.
  
 
 0.942
ENSCAPP00000011327
annotation not available
  
 
 0.934
SIRT1
Sirtuin 1.
    
 0.933
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.