close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MEGF8Multiple EGF like domains 8. (2659 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor.
     
 0.916
MGRN1
Mahogunin ring finger 1.
   
 
 0.830
RNF157
Ring finger protein 157.
   
 
 0.726
TBC1D31
TBC1 domain family member 31.
    
 0.713
PAFAH1B1
Platelet activating factor acetylhydrolase 1b regulatory subunit 1.
    
 0.713
AP3D1
Adaptor related protein complex 3 subunit delta 1.
    
 0.627
AP2A1
Adaptor related protein complex 2 subunit alpha 1.
    
  0.610
COL4A1
Collagen type IV alpha 1 chain.
      
 0.564
ENSCAPP00000013876
annotation not available
    
  0.554
MOSMO
Modulator of smoothened.
      
 0.548
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.