MEGF8 protein (Cavia aperea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MEGF8

Multiple EGF like domains 8. (2659 aa)

Predicted Functional Partners:

MGRN1

0.984

SMO

0.947

MOSMO

0.940

ANKRD46

0.927

ENSCAPP00000018089

0.824

RNF157

0.787

PLA2G4A

0.756

TBC1D31

0.679

ZEB1

0.670

COL4A1

0.656

Your Current Organism:

Cavia aperea

NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD46	ENSCAPP00000018089	ENSCAPP00000017020	ENSCAPP00000018089	Ankyrin repeat domain 46.	annotation not available	0.811
ANKRD46	MEGF8	ENSCAPP00000017020	ENSCAPP00000006526	Ankyrin repeat domain 46.	Multiple EGF like domains 8.	0.927
ANKRD46	MGRN1	ENSCAPP00000017020	ENSCAPP00000016398	Ankyrin repeat domain 46.	Mahogunin ring finger 1.	0.959
ANKRD46	RNF157	ENSCAPP00000017020	ENSCAPP00000007878	Ankyrin repeat domain 46.	Ring finger protein 157.	0.745
COL4A1	MEGF8	ENSCAPP00000017765	ENSCAPP00000006526	Collagen type IV alpha 1 chain.	Multiple EGF like domains 8.	0.656
COL4A1	PLA2G4A	ENSCAPP00000017765	ENSCAPP00000018609	Collagen type IV alpha 1 chain.	Phospholipase A2 group IVA.	0.482
COL4A1	ZEB1	ENSCAPP00000017765	ENSCAPP00000011582	Collagen type IV alpha 1 chain.	Zinc finger E-box binding homeobox 1.	0.478
ENSCAPP00000018089	ANKRD46	ENSCAPP00000018089	ENSCAPP00000017020	annotation not available	Ankyrin repeat domain 46.	0.811
ENSCAPP00000018089	MEGF8	ENSCAPP00000018089	ENSCAPP00000006526	annotation not available	Multiple EGF like domains 8.	0.824
ENSCAPP00000018089	MGRN1	ENSCAPP00000018089	ENSCAPP00000016398	annotation not available	Mahogunin ring finger 1.	0.635
MEGF8	ANKRD46	ENSCAPP00000006526	ENSCAPP00000017020	Multiple EGF like domains 8.	Ankyrin repeat domain 46.	0.927
MEGF8	COL4A1	ENSCAPP00000006526	ENSCAPP00000017765	Multiple EGF like domains 8.	Collagen type IV alpha 1 chain.	0.656
MEGF8	ENSCAPP00000018089	ENSCAPP00000006526	ENSCAPP00000018089	Multiple EGF like domains 8.	annotation not available	0.824
MEGF8	MGRN1	ENSCAPP00000006526	ENSCAPP00000016398	Multiple EGF like domains 8.	Mahogunin ring finger 1.	0.984
MEGF8	MOSMO	ENSCAPP00000006526	ENSCAPP00000014663	Multiple EGF like domains 8.	Modulator of smoothened.	0.940
MEGF8	PLA2G4A	ENSCAPP00000006526	ENSCAPP00000018609	Multiple EGF like domains 8.	Phospholipase A2 group IVA.	0.756
MEGF8	RNF157	ENSCAPP00000006526	ENSCAPP00000007878	Multiple EGF like domains 8.	Ring finger protein 157.	0.787
MEGF8	SMO	ENSCAPP00000006526	ENSCAPP00000015813	Multiple EGF like domains 8.	Smoothened, frizzled class receptor.	0.947
MEGF8	TBC1D31	ENSCAPP00000006526	ENSCAPP00000000307	Multiple EGF like domains 8.	TBC1 domain family member 31.	0.679
MEGF8	ZEB1	ENSCAPP00000006526	ENSCAPP00000011582	Multiple EGF like domains 8.	Zinc finger E-box binding homeobox 1.	0.670