STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUMBLNUMB like endocytic adaptor protein. (562 aa)    
Predicted Functional Partners:
NOTCH1
Notch receptor 1.
    
 0.969
NOTCH2
Notch receptor 2.
    
 0.949
AP2A1
Adaptor related protein complex 2 subunit alpha 1.
    
 0.915
NOTCH3
Notch receptor 3.
    
 0.865
NOTCH4
Notch receptor 4.
    
 0.859
ITCH
Itchy E3 ubiquitin protein ligase.
    
 0.836
GAK
Cyclin G associated kinase.
   
 
 0.826
NUMB
NUMB endocytic adaptor protein.
  
  
 
0.805
LNX1
Ligand of numb-protein X 1.
    
 
 0.745
EPS15
Epidermal growth factor receptor pathway substrate 15.
    
 
 0.734
Your Current Organism:
Cavia aperea
NCBI taxonomy Id: 37548
Other names: Brazilian guinea pig, C. aperea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.