node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ga0061063_0537 | glyA | GCA_001418035_00336 | GCA_001418035_00790 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.874 |
Ga0061063_0537 | purA | GCA_001418035_00336 | GCA_001418035_02214 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.999 |
Ga0061063_0537 | purC | GCA_001418035_00336 | GCA_001418035_01641 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Belongs to the SAICAR synthetase family. | 0.998 |
Ga0061063_0537 | purD | GCA_001418035_00336 | GCA_001418035_00646 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Belongs to the GARS family. | 0.979 |
Ga0061063_0537 | purE | GCA_001418035_00336 | GCA_001418035_01639 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.975 |
Ga0061063_0537 | purF | GCA_001418035_00336 | GCA_001418035_01181 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.970 |
Ga0061063_0537 | purH | GCA_001418035_00336 | GCA_001418035_00648 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein. | 0.997 |
Ga0061063_0537 | purL | GCA_001418035_00336 | GCA_001418035_01252 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.980 |
Ga0061063_0537 | purM | GCA_001418035_00336 | GCA_001418035_00212 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein. | 0.949 |
Ga0061063_0537 | purN | GCA_001418035_00336 | GCA_001418035_00213 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.959 |
glyA | Ga0061063_0537 | GCA_001418035_00790 | GCA_001418035_00336 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.874 |
glyA | purA | GCA_001418035_00790 | GCA_001418035_02214 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.867 |
glyA | purC | GCA_001418035_00790 | GCA_001418035_01641 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Belongs to the SAICAR synthetase family. | 0.803 |
glyA | purD | GCA_001418035_00790 | GCA_001418035_00646 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Belongs to the GARS family. | 0.927 |
glyA | purF | GCA_001418035_00790 | GCA_001418035_01181 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.844 |
glyA | purH | GCA_001418035_00790 | GCA_001418035_00648 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein. | 0.994 |
glyA | purL | GCA_001418035_00790 | GCA_001418035_01252 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.986 |
glyA | purM | GCA_001418035_00790 | GCA_001418035_00212 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein. | 0.673 |
glyA | purN | GCA_001418035_00790 | GCA_001418035_00213 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.974 |
purA | Ga0061063_0537 | GCA_001418035_02214 | GCA_001418035_00336 | Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.999 |