node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFR50860.1 | SFR60185.1 | SAMN04488073_2527 | SAMN04488073_3274 | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL. | 0.980 |
SFR50860.1 | SFR60625.1 | SAMN04488073_2527 | SAMN04488073_3329 | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | Glutamate synthase (NADPH/NADH) large chain. | 0.738 |
SFR50860.1 | glnD | SAMN04488073_2527 | SAMN04488073_3130 | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | UTP--GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.954 |
SFR50860.1 | glnE | SAMN04488073_2527 | SAMN04488073_3283 | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.588 |
SFR58376.1 | SFR58380.1 | SAMN04488073_3128 | SAMN04488073_3129 | Arsenate reductase; Belongs to the ArsC family. | Succinyldiaminopimelate aminotransferase apoenzyme. | 0.790 |
SFR58376.1 | dapD | SAMN04488073_3128 | SAMN04488073_3127 | Arsenate reductase; Belongs to the ArsC family. | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.656 |
SFR58376.1 | dapE | SAMN04488073_3128 | SAMN04488073_3126 | Arsenate reductase; Belongs to the ArsC family. | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.742 |
SFR58376.1 | glnD | SAMN04488073_3128 | SAMN04488073_3130 | Arsenate reductase; Belongs to the ArsC family. | UTP--GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.790 |
SFR58376.1 | map | SAMN04488073_3128 | SAMN04488073_3131 | Arsenate reductase; Belongs to the ArsC family. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.790 |
SFR58380.1 | SFR58376.1 | SAMN04488073_3129 | SAMN04488073_3128 | Succinyldiaminopimelate aminotransferase apoenzyme. | Arsenate reductase; Belongs to the ArsC family. | 0.790 |
SFR58380.1 | SFR60625.1 | SAMN04488073_3129 | SAMN04488073_3329 | Succinyldiaminopimelate aminotransferase apoenzyme. | Glutamate synthase (NADPH/NADH) large chain. | 0.894 |
SFR58380.1 | dapD | SAMN04488073_3129 | SAMN04488073_3127 | Succinyldiaminopimelate aminotransferase apoenzyme. | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.985 |
SFR58380.1 | dapE | SAMN04488073_3129 | SAMN04488073_3126 | Succinyldiaminopimelate aminotransferase apoenzyme. | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.986 |
SFR58380.1 | glnD | SAMN04488073_3129 | SAMN04488073_3130 | Succinyldiaminopimelate aminotransferase apoenzyme. | UTP--GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.790 |
SFR58380.1 | map | SAMN04488073_3129 | SAMN04488073_3131 | Succinyldiaminopimelate aminotransferase apoenzyme. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.804 |
SFR60185.1 | SFR50860.1 | SAMN04488073_3274 | SAMN04488073_2527 | Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL. | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | 0.980 |
SFR60185.1 | SFR60625.1 | SAMN04488073_3274 | SAMN04488073_3329 | Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL. | Glutamate synthase (NADPH/NADH) large chain. | 0.579 |
SFR60185.1 | glnD | SAMN04488073_3274 | SAMN04488073_3130 | Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL. | UTP--GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.631 |
SFR60625.1 | SFR50860.1 | SAMN04488073_3329 | SAMN04488073_2527 | Glutamate synthase (NADPH/NADH) large chain. | Nitrogen regulatory protein P-II family; Belongs to the P(II) protein family. | 0.738 |
SFR60625.1 | SFR58380.1 | SAMN04488073_3329 | SAMN04488073_3129 | Glutamate synthase (NADPH/NADH) large chain. | Succinyldiaminopimelate aminotransferase apoenzyme. | 0.894 |